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Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex.
The crystal structure of Norrin is reported, which reveals a unique dimeric structure with each monomer adopting a conserved cystine knot fold, which provides crucial insights into the assembly and activation of the Norrin-Fz4-Lrp5/6 signaling complex.
Structural basis of JAZ repression of MYC transcription factors in jasmonate signaling
Arabidopsis MYC3 undergoes pronounced conformational changes when bound to the conserved Jas motif of the JAZ9 repressor, which elucidate a dynamic molecular switch mechanism that governs the repression and activation of a major plant hormone pathway.
Structural basis for molecular recognition of folic acid by folate receptors
The extensive interactions between the receptor and ligand readily explain the high folate-binding affinity of folate receptors and provide a template for designing more specific drugs targeting the folate receptor system.
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
The crystal structure of a constitutively active form of human rhodopsin bound to a pre-activated form of the mouse visual arrestin is determined by serial femtosecond X-ray laser crystallography and provides a basis for understanding GPCR-mediated arrestin-biased signalling.
LRP5 and LRP6 in development and disease
Structural basis of the Norrin-Frizzled 4 interaction
Structural basis for RNA recognition by a dimeric PPR-protein complex
A new model of RNA recognition by RNA-induced formation of an asymmetric dimer of a PPR protein is established by the identification of multiple THA8-binding sites in the ycf3 intron and the present crystal structures of Brachypodium distachyonTHA8.
Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway.
- Geoff P. Horsman, J. Ke, Shao‐Bo Dai, S. Seah, J. Bolin, L. Eltis
- Chemistry, BiologyBiochemistry
- 19 September 2006
Kinetic and structural analyses of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid (HOPDA) hydrolase from Burkholderia xenovorans LB400 (BphD(LB400)) provide insight into the catalytic mechanism of…
Structural and Functional Study of d-Glucuronyl C5-epimerase*
The crystal structures of Glce in apo-form and in complex with heparin hexasaccharide, both in a stable dimer conformation are determined, advancing understanding of the key modification in HS biosynthesis.
Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors
Sequence alignments and structure-based mutagenesis indicate that this mode of corepressor binding is highly conserved in a large set of transcriptional repressors, thus providing a general mechanism for gene repression mediated by the TPL family of core Pressors.