• Publications
  • Influence
Vitamin E and donepezil for the treatment of mild cognitive impairment.
BACKGROUND Mild cognitive impairment is a transitional state between the cognitive changes of normal aging and early Alzheimer's disease. METHODS In a double-blind study, we evaluated subjects withExpand
  • 1,567
  • 59
  • PDF
Context processing in older adults: evidence for a theory relating cognitive control to neurobiology in healthy aging.
A theory of cognitive aging is presented in which healthy older adults are hypothesized to suffer from disturbances in the processing of context that impair cognitive control function across multipleExpand
  • 338
  • 54
  • PDF
Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and twoExpand
  • 1,390
  • 51
  • PDF
Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging and the Alzheimer's Association workgroup
The pathophysiological process of Alzheimer’s disease (AD) is thought to begin many years before the diagnosis of AD dementia. This long “preclinical” phase of AD would provide a critical opportunityExpand
  • 504
  • 45
  • PDF
Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
A molecular test for Alzheimer's disease could lead to better treatment and therapies. We found 18 signaling proteins in blood plasma that can be used to classify blinded samples from Alzheimer's andExpand
  • 927
  • 42
  • PDF
Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials.
BACKGROUND Mild cognitive impairment (MCI) represents a transitional state between the cognitive changes of normal aging and very early dementia and is becoming increasingly recognized as a riskExpand
  • 813
  • 32
  • PDF
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions
Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. The predominant neuropathology is FTLD with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP).Expand
  • 392
  • 29
  • PDF
Analysis of shared heritability in common disorders of the brain
Brainstorming diseases Consistent classification of neuropsychiatric diseases is problematic because it can lead to misunderstanding of etiology. The Brainstorm Consortium examined multipleExpand
  • 686
  • 22
  • PDF
Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases
Here, we investigated if TAR-DNA-binding protein-43 (TDP-43), the disease protein in frontotemporal lobar degeneration and ubiquitin inclusions with or without motor neuron disease as well asExpand
  • 317
  • 21
  • PDF
Parkinson's disease is associated with hippocampal atrophy
Patients with Parkinson's disease (PD) may have hippocampal atrophy compared with controls. We compared hippocampal, and extra‐hippocampal volumes between PD, PDD (patients with PD who have mildExpand
  • 275
  • 21