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Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans
Generation of Swine Flu As the newly emerged influenza virus starts its journey to infect the world's human population, the genetic secrets of the 2009 outbreak of swine influenza A(H1N1) are beingExpand
Transmission of Equine Influenza Virus to Dogs
TLDR
The geographic expansion of the infection and its persistence for several years indicate efficient transmission of canine influenza virus among greyhounds, and evidence of infection in pet dogs suggests that this infection may also become enzootic in this population. Expand
Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus.
TLDR
Vaccination with recent seasonal nonadjuvanted or adjuvanted influenza vaccines induced little or no cross-reactive antibody response to 2009 H1N1 in any age group. Expand
Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness.
TLDR
An avian H5N1 influenza A virus was isolated from a tracheal aspirate obtained from a 3-year-old child in Hong Kong with a fatal illness consistent with influenza, causing 87.5 to 100 percent mortality in experimentally inoculated White Plymouth Rock and White Leghorn chickens. Expand
Cutting Edge: Impaired Toll-Like Receptor Expression and Function in Aging
TLDR
Results support the concept that increased susceptibility to infections and poor adaptive immune responses in aging may be due to the decline in TLR expression and function. Expand
Transmission and Pathogenesis of Swine-Origin 2009 A(H1N1) Influenza Viruses in Ferrets and Mice
TLDR
Although results were variable, it seems that the 2009 A(H1N1) virus may be less efficiently transmitted by respiratory droplets in comparison to the highly transmissible seasonal H1n1 virus, suggesting that additional virus adaptation in mammals may be required before the authors see phenotypes observed in earlier pandemics. Expand
H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice
TLDR
Investigation of the cellular immune response to infection in the mouse lung by flow cytometry shows that infection with HP influenza viruses such as H5N1 and the 1918 pandemic virus leads to a rapid cell recruitment of macrophages and neutrophils into the lungs, suggesting that these cells play a role in acute lung inflammation associated with HP virus infection. Expand
Detection of Antibody to Avian Influenza A (H5N1) Virus in Human Serum by Using a Combination of Serologic Assays
TLDR
A more sensitive microneutralization assay is developed to detect antibodies to avian influenza in humans and is being used for the seroepidemiologic investigations of the avian H5N1 influenza outbreak. Expand
Community-acquired pneumonia requiring hospitalization among U.S. children.
TLDR
The burden of hospitalization for children with community-acquired pneumonia was highest among the very young, with respiratory viruses the most commonly detected causes of pneumonia. Expand
A Two-Amino Acid Change in the Hemagglutinin of the 1918 Influenza Virus Abolishes Transmission
TLDR
These findings confirm an essential role of hemagglutinin receptor specificity for the transmission of influenza viruses among mammals and suggest that a predominant human α-2,6 sialic acid binding preference is essential for optimal transmission of this pandemic virus. Expand
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