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Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration
PET imaging data demonstrate that alterations in an organism's environment can produce profound biological changes that have important behavioral associations, including vulnerability to cocaine addiction. Expand
Old world nonhuman primate models of type 2 diabetes mellitus.
- J. Wagner, K. Kavanagh, Gina M Ward, B. Auerbach, H. J. Harwood, J. Kaplan
- Biology, Medicine
- ILAR journal
Old World NHPs are a valuable animal model of type 2 diabetes to study disease progression, associated risk factors, and potential new treatments and recently developed agonists of the peroxisome proliferators-activated receptors are used. Expand
Social Impulsivity Inversely Associated with CSF 5-HIAA and Fluoxetine Exposure in Vervet Monkeys
- L. Fairbanks, W. Melega, M. Jorgensen, J. Kaplan, M. Mcguire
- Psychology, Medicine
- 1 April 2001
Evidence for serotonergic influences on social impulsivity is provided in male vervet monkeys using a standardized test of impulsivity in a social context: the Intruder Challenge. Expand
Chronic Social Stress, Social Status, and Susceptibility to Upper Respiratory Infections in Nonhuman Primates
Although the social instability manipulation was associated with increased agonistic behavior as indicated by minor injuries and elevated norepinephrine responses to social reorganizations, the manipulation did not influence the probability of being infected by the virus. Expand
Inhibition of coronary artery atherosclerosis by 17-beta estradiol in ovariectomized monkeys. Lack of an effect of added progesterone.
It is concluded that physiologic estrogen replacement Therapy with or without added progesterone inhibits atherosclerosis progression in ovariectomized monkeys, which may explain why estrogen replacement therapy results in reduced risk of coronary heart disease in postmenopausal women. Expand
Social Status, Environment, and Atherosclerosisin Cynomolgus Monkeys
The results suggest that social dominance (an Individual behavioral characteristic) Is associated with increased coronary artery atherosclerosis, but only under social conditions that provide recurrent threats to the status of dominant animals (I.e., under behavioral challenge). Expand
Impairment of ovarian function and associated health-related abnormalities are attributable to low social status in premenopausal monkeys and not mitigated by a high-isoflavone soy diet.
BACKGROUND Psychological stress may impair premenopausal ovarian function and contribute to risk for chronic disease. Soy isoflavones may also influence ovarian function and affect health. Here, we… Expand
Fight interference and altruism in rhesus monkeys
- J. Kaplan
- 1 August 1978
Fight interference data from a group of free-ranging rhesus monkeys at Cayo Santiago were used to test hypotheses about the evolution and importance of altruism. Both females and natal males (those… Expand
Effects of androgens on coronary artery atherosclerosis and atherosclerosis-related impairment of vascular responsiveness.
It is concluded that an experimentally induced male plasma androgen pattern results in exacerbation of diet-induced atherosclerosis-related arterial remodeling in female monkeys. Expand
Endothelial dysfunction in response to psychosocial stress in monkeys.
Results indicate that social disruption is associated with both sympathetic nervous system arousal and indexes of endothelial dysfunction, effects that may be prevented by treatment with a beta-adrenergic blocking agent. Expand