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The GABAergic nervous system of Caenorhabditis elegans
How these GABAergic neurons act to control the body and enteric muscles necessary for different behaviours is deduced on the basis of the ultrastructurally defined connectivity of the C. elegans nervous system. Expand
Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis.
Evidence is presented that mutations in the gene encoding alpha-actinin-4 (ACTN4) are the cause of disease in three families with an autosomal dominant form of FSGS, and Regulation of the actin cytoskeleton of glomerular podocytes may be altered in this group of patients. Expand
Mutations in ACTN4, encoding α-actinin-4, cause familial focal segmental glomerulosclerosis
Evidence is presented that mutations in the gene encoding α-actinin-4 (ACTN4) are the cause of disease in three families with an autosomal dominant form of FSGS, and Regulation of the actin cytoskeleton of glomerular podocytes may be altered in this group of patients. Expand
A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans.
It is shown that three classes of neurons (ASH, FLP, and OLQ) sense touch to the nose and hence are required for this avoidance response, and that C. elegans has at least five morphologically distinct classes of mechanosensory neurons. Expand
Synaptic code for sensory modalities revealed by C. elegans GLR-1 glutamate receptor
A genetic analysis of sensory modality coding in Caenorhabditis elegans suggests that GLR-1 receptors act in synaptic targets of the ASH neurons, and proposes that discrimination between theASH sensory modalities arises from differential release of ASH neurotransmitters in response to different stimuli. Expand
PKC-1 regulates secretion of neuropeptides
It is shown that protein kinase C-1 (PKC-1), which is most similar to the vertebrate PKC η and ε isoforms, regulates exocytosis of DCVs in Caenorhabditis elegans motor neurons and selectively regulates DCV release from neurons. Expand
LIN-10 Is a Shared Component of the Polarized Protein Localization Pathways in Neurons and Epithelia
Testing the model that neurons and epithelial cells use a shared mechanism for polarized protein sorting by comparing the pathways for localizing basolateral and postsynaptic proteins in C. elegans found that these interneurons utilize at least two separate post Synaptic localization pathways. Expand
Systematic analysis of genes required for synapse structure and function
A systematic screen to identify genes required for the function or development of Caenorhabditis elegans neuromuscular junctions identified groups of functionally related genes, including those involved in the synaptic vesicle cycle, neuropeptide signalling and responsiveness to phorbol esters. Expand
Facilitation of Synaptic Transmission by EGL-30 Gqα and EGL-8 PLCβ DAG Binding to UNC-13 Is Required to Stimulate Acetylcholine Release
It is suggested that presynaptic DAG facilitates synaptic transmission and that part of this effect is mediated by UNC-13, which is found to accumulate in punctate structures in the ventral nerve cord. Expand
Serotonin Inhibition of Synaptic Transmission Gαo Decreases the Abundance of UNC-13 at Release Sites
We show that serotonin inhibits synaptic transmission at C. elegans neuromuscular junctions, and we describe a signaling pathway that mediates this effect. Release of acetylcholine from motor neurons… Expand