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Pathogenic Escherichia coli
Few microorganisms are as versatile as Escherichia coli; it can also be a highly versatile, and frequently deadly, pathogen. Expand
Diarrheagenic Escherichia coli
The current level of understanding of the pathogenesis of the diarrheagenic E. coli strains is discussed and how their pathogenic schemes underlie the clinical manifestations, diagnostic approach, and epidemiologic investigation of these important pathogens are described. Expand
A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens.
It is reported that in EPEC a 35-kbp locus containing several regions implicated in formation of these lesions is found, which hybridize to E. coli O157:H7 and other pathogens of three genera that cause similar lesions but do not hybridized to avirulent members of the same species. Expand
The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli E2348/69
The entire LEE of EPEC strain E2348/69 is sequenced and the final LEE sequence entry contains corrections to some of these previously reported genes and predicted proteins and changes the name of several previously described genes comprising the type III secretion system ofEPEC. Expand
Pathogenicity islands and the evolution of microbes.
Genomic islands are present in the majority of genomes of pathogenic as well as nonpathogenic bacteria and may encode accessory functions which have been previously spread among bacterial populations and are argued for the generation of pathogenicity islands by horizontal gene transfer. Expand
Bacteria–host communication: The language of hormones
It is shown that an EHEC luxS mutant, unable to produce the bacterial autoinducer, still responds to a eukaryotic cell signal to activate expression of its virulence genes, implying a potential cross-communication between the luxS/AI-3 bacterial QS system and the epinephrine host signaling system. Expand
A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells.
The ability of enteropathogenic Escherichia coli to form attaching and effacing intestinal lesions is a major characteristic of EPEC pathogenesis and a chromosomal gene (eae) that is necessary for this activity is identified using TnphoA mutagenesis. Expand
Association of Genomic O Island 122 of Escherichia coli EDL 933 with Verocytotoxin-Producing Escherichia coli Seropathotypes That Are Linked to Epidemic and/or Serious Disease
ABSTRACT The distribution of EDL 933 O island 122 (OI-122) was investigated in 70 strains of Verocytotoxin-producing Escherichia coli (VTEC) of multiple serotypes that were classified into fiveExpand
The Per regulon of enteropathogenic Escherichia coli : identification of a regulatory cascade and a novel transcriptional activator, the locus of enterocyte effacement (LEE)‐encoded regulator (Ler)
The genetic organization of the LEE is determined, defining transcriptional units and mapping transcriptional start points, and components of the type III secretion system are transcribed from three polycistronic operons designated LEE1, LEE2 and LEE3. Expand
Quorum sensing controls expression of the type III secretion gene transcription and protein secretion in enterohemorrhagic and enteropathogenic Escherichia coli.
Enterohemorrhagic Escherichia coli O157:H7, which has an unusually low infectious dose, could be induced by quorum sensing of signals produced by nonpathogenic E. coli of the normal intestinal flora. Expand