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Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors
It is shown that dying tumor cells release ATP, which then acts on P2X7 purinergic receptors from DCs and triggers the NOD-like receptor family, pyrin domain containing-3 protein (NLRP3)-dependent caspase-1 activation complex ('inflammasome'), allowing for the secretion of interleukin-1 β (IL-1β). Expand
Extracellular ATP is a danger signal activating P2X7 receptor in lung inflammation and fibrosis.
The role of extracellular adenosine triphosphate (eATP) in pulmonary inflammation and fibrosis is addressed and ATP released from BLM-injured lung cells constitutes a major endogenous danger signal that engages the P2X(7) receptor/pannexin-1 axis, leading to IL-1β maturation and lung fibrosis. Expand
A direct estimate of the human alphabeta T cell receptor diversity.
In this study, TCR gene amplification and sequencing showed that there are about 10(6) different beta chains in the blood, each pairing, on the average, with at least 25 different alpha chains. Expand
A Direct Estimate of the Human αβ T Cell Receptor Diversity
TCR gene amplification and sequencing showed that the naive repertoire is highly diverse, whereas the memory compartment, here one-third of the T cell population, contributes less than 1 percent of the total diversity. Expand
Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth
How activation of the Nlrp3 inflammasome in MDSCs by 5FU and Gem limits the antitumor efficacy of these chemotherapeutic agents is identified. Expand
Size Estimate of the αβ TCR Repertoire of Naive Mouse Splenocytes1
The size of the TCR-αβ repertoire of naive mouse T splenocytes is measured for the first time and it is found that the mouse spleen harbors about 2 × 106 clones of about 10 cells each, which is still large enough to maintain a high functional diversity. Expand
IL-33 Enhances Lipopolysaccharide-Induced Inflammatory Cytokine Production from Mouse Macrophages by Regulating Lipopolysaccharide Receptor Complex1
It is found that IL-33 actually enhances the LPS response of macrophages and does not induce LPS desensitization, and this effect is mediated by the ST2 receptor because it is not found in ST2 knockout mice. Expand
The Purinergic Receptor P2X7 Triggers α-Secretase-dependent Processing of the Amyloid Precursor Protein*
It is demonstrated that the mitogen-activated protein kinase modules Erk1/2 and JNK are involved in P2X7R-dependent α-secretase activity, which suggests that P2 X7R, which is expressed in hippocampal neurons and glial cells, is a potential therapeutic target in AD. Expand
The Pro-451 to Leu Polymorphism within the C-terminal Tail of P2X7 Receptor Impairs Cell Death but Not Phospholipase D Activation in Murine Thymocytes*
It is found that extracellular ATP (ATPe) induces a caspase-dependent apoptosis of BALB/c thymocytes, as observed by DNA fragmentation, and that cell death and PC-PLD activity are regulated through distinct domains of the P2X7R. Expand
Public and private V beta T cell receptor repertoires against hen egg white lysozyme (HEL) in nontransgenic versus HEL transgenic mice
We have previously produced a transgenic mouse line for hen egg lysozyme (HEL), an experimental model for analyzing tolerance to self- antigens at the peptide level. We have now characterizedExpand