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Quantitative immunofluorescence mapping reveals little functional coclustering of proteins within platelet α-granules.
Platelets are small anucleate blood cells that aggregate to seal leaks at sites of vascular injury and are important in the pathology of atherosclerosis, acute coronary syndromes, rheumatoidExpand
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Electron Tomography Reveals Rab6 Is Essential to the Trafficking of trans‐Golgi Clathrin and COPI‐Coated Vesicles and the Maintenance of Golgi Cisternal Number
We have shown previously that Rab6, a small, trans‐Golgi‐localized GTPase, acts upstream of the conserved oligomeric Golgi complex (COG) and ZW10/RINT1 retrograde tether complexes to maintain GolgiExpand
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Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation
Collagen is a major component of the extracellular matrix and its integrity is essential for connective tissue and organ function. The importance of proteins involved in intracellular collagenExpand
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STEM tomography reveals that the canalicular system and α‐granules remain separate compartments during early secretion stages in blood platelets
Essentials How platelets organize their α‐granule cargo and use their canalicular system remains controversial. Past structural studies were limited due to small sampling volumes or decreasedExpand
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SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets.
Platelet α-granule cargo release is fundamental to both hemostasis and thrombosis. Granule matrix hydration is a key regulated step in this process, yet its mechanism is poorly understood. InExpand
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3D ultrastructural analysis of α‐granule, dense granule, mitochondria, and canalicular system arrangement in resting human platelets
State‐of‐the‐art 3‐dimensional (3D) electron microscopy approaches provide a new standard for the visualization of human platelet ultrastructure. Application of these approaches to platelets rapidlyExpand
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Canalicular system reorganization during mouse platelet activation as revealed by 3D ultrastructural analysis.
The canalicular system (CS) has been defined as: 1) an inward, invaginated membrane connector that supports entry into and exit from the platelet; 2) a static structure stable during plateletExpand
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Managing the Introduction of Super-Resolution Microscopy into a Core Facility.
Super resolution techniques place the resolution of fluorescence microscopy closer to the size of the underlying cell structure or molecular machine being studied. Expand
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Reduction in SNAP-23 Alters Microfilament Organization in Myofibrobastic Hepatic Stellate Cells.
Hepatic stellate cells (HSC) are critical effector cells of liver fibrosis. In the injured liver, HSC differentiate into a myofibrobastic phenotype. A critical feature distinguishing myofibroblasticExpand