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Conditioned place preference using opiate and stimulant drugs: A meta-analysis
TLDR
A meta-analysis of data obtained from published articles that have used the conditioned place preference (CPP) paradigm to assess the rewarding effects of morphine, heroin, amphetamine and cocaine in rats revealed that several methodological variables moderated the effect size for CPP, at least with some of the drugs examined. Expand
Cocaine Administered into the Medial Prefrontal Cortex Reinstates Cocaine-Seeking Behavior by Increasing AMPA Receptor-Mediated Glutamate Transmission in the Nucleus Accumbens
TLDR
An animal model of cocaine relapse shows that AMPA and NMDA receptors in the nucleus accumbens have opposing roles in the reinstatement of cocaine-seeking behavior, and indicates that the glutamatergic pathway from the mPFC to the nucleus Accumbens plays an important role in cocaine priming-induced reinstate of drug seeking. Expand
Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists.
TLDR
The results suggest that D1- and D2-like receptors play fundamentally different roles in the relapse process, and either stimulation or blockade of D1 -like receptors appears to be inhibitory with respect to relapse. Expand
Environmental enrichment attenuates locomotor sensitization, but not in vitro dopamine release, induced by amphetamine
TLDR
No differences between EC and IC rats in release of DA or DOPAC were evident, suggesting that the environmentally induced difference in sensitivity to the behavioral effects of amphetamine involves a neural mechanism extrinsic to the mesolimbic and nigrostriatal terminal field regions. Expand
Attenuation of Behavioral Effects of Cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in Squirrel Monkeys: Comparison with Dizocilpine
TLDR
The findings point to a significant contribution of mGluR5 mechanisms in the behavioral effects of cocaine related to its abuse and suggest that MPEP has properties of a functional cocaine antagonist, which are not secondary to antagonism at NMDA receptors. Expand
The effect of environmental enrichment on amphetamine-stimulated locomotor activity, dopamine synthesis and dopamine release
TLDR
The failure of amphetamine to produce differential neurochemical effects in EC and IC rats in vitro may be because this experiment eliminated either pharmacokinetic effects or neurochemical differences in brain regions outside the NA and Str. Expand
Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates.
TLDR
The results provide evidence in nonhuman primates that alpha1GABAA receptors do not play a key role in the anxiolytic and muscle-relaxant properties of benzodiazepine-type drugs; instead, these effects involve alpha2GabAA, alpha3GABaa, and/or alpha5GAB AA subtypes. Expand
Pharmacological and Environmental Determinants of Relapse to Cocaine-Seeking Behavior
TLDR
Animal models have provided valuable information about pharmacological and environmental factors that precipitate reinstatement of extinguished cocaine-seeking in rats and monkeys, as well as new insights about potential pharmacotherapies for relapse prevention, suggesting that some of these drugs may be viable candidates for development as antirelapse pharmacotheraps. Expand
Abuse and dependence liability of benzodiazepine-type drugs: GABAA receptor modulation and beyond
TLDR
This review examines the behavioral determinants of the abuse and dependence liability of benzodiazepine-type drugs and the pharmacological and putative biochemical basis of the Abuse-related behavior is discussed. Expand
κ Agonist-Induced Reinstatement of Cocaine Seeking in Squirrel Monkeys: A Role for Opioid and Stress-Related Mechanisms
TLDR
Interactions between a subpopulation of κ opioid receptors and central corticotropin-releasing factor and noradrenergic stress systems in the reinstatement of cocaine seeking induced by κ agonists are pointed to. Expand
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