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Comparative Studies on Conventional and Microwave Synthesis of Some Benzimidazole, Benzothiazole and Indole Derivatives and Testing on Inhibition of Hyaluronidase
We have synthesized twelve 2-substituted benzimidazole, benzothiazole and indole derivatives using on both microwave irradiation and conventional heating methods. The microwave method was observed toExpand
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Autodisplay of streptavidin.
Streptavidin was expressed on the outer membrane of E. coli as a recombinant fusion protein with an autotransporter domain called AIDA-I (adhesin involved in diffuse adherence) using autodisplayExpand
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Synthesis and biological evaluation of flexible and conformationally constrained LpxC inhibitors.
Inhibitors of the UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase (LpxC) represent promising candidates for the development of antibiotics possessing a so far unexploited mechanismExpand
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The Staphylococcus xylosus C2a urease was purified 655-fold to a maximum specific activity of 1 573 U/mg and contained three non-identical subunits (64, 17.8 and 16.3 kDa). The purified urease had aExpand
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Threonine is present instead of cysteine at the active site of urease from Staphylococcus xylosus
DNA sequence analysis of the stuctural urease genes from Staphylococcus xylosus revealed that three enzyme subunits are encoded in the order of 11000, 15400 and 61000 (mol. mass), which correspond toExpand
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Identification of novel CK2 inhibitors with a benzofuran scaffold by novel non-radiometric in vitro assays
Protein kinase CK2 is emerging as a target in neoplastic diseases. Inhibition of CK2 by small compounds could lead to new therapies by counteracting the elevated CK2 activities found in a variety ofExpand
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1H and 13C NMR assignments of bioactive indeno[1,2‐b]indole‐10‐one derivatives
The complete 1H and 13C assignments of eight bioactive indeno[1,2‐b]indole‐10‐one derivatives were accomplished by the combined use of one‐dimensional and two‐dimensional NMR experiments. Copyright ©Expand
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Microwave-assisted oxidation of indan-1-ones into ninhydrins
Abstract A simple and general microwave-assisted selenium oxidation has been developed for the synthesis of substituted ninhydrins from indan-1-ones in order to access to indeno[1,2- b ]indolesExpand
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Site-directed mutagenesis of cysteine to threonine in Proteus vulgaris urease active site increases enzyme activity and stability
Cysteine-319 belongs to the flexible flap at the active site of Proteus vulgaris urease. Replacing this cysteine by threonine resulted in a 20-fold increase of specific activity. TemperatureExpand
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