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Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II.
TLDR
This report provides the best available prevalence estimates for the US for osteoarthritis, polymyalgia rheumatica, gout, fibromyalgia, and carpal tunnel syndrome as well as the symptoms of neck and back pain. Expand
Osteoarthritis: New Insights. Part 1: The Disease and Its Risk Factors
TLDR
This article is part 1 of a two-part summary of an NIH conference, Stepping Away with OA: Prevention of Onset, Progression, and Disability of Osteoarthritis, which brought together experts in osteoarth arthritis from diverse backgrounds and provided a multidisciplinary and comprehensive summary of recent advances in the prevention. Expand
Lifetime risk of symptomatic knee osteoarthritis.
TLDR
Nearly half of the adults in Johnston County will develop symptomatic knee OA by age 85 years, with lifetime risk highest among obese persons, which underscores the immediate need for greater use of clinical and public health interventions, especially those that address weight loss and self-management. Expand
Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project.
TLDR
Policy should be directed to increasing education of the public and the medical community about the high prevalence of knee-related osteoarthritis conditions, especially in these subgroups, to decrease their impact and ultimately prevent them. Expand
A systematic review of recommendations and guidelines for the management of osteoarthritis: The chronic osteoarthritis management initiative of the U.S. bone and joint initiative.
TLDR
The relative agreement on many OA management recommendations across organizations indicates a problem with dissemination and implementation rather than a lack of quality guidelines, and future efforts should focus on optimizing implementation in primary care settings. Expand
Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity
TLDR
It is shown that variation within the coding sequence of the gene encoding the P2X7 receptor (P2X8R) affects chronic pain sensitivity in both mice and humans, and that selectively targeting P2x7R pore formation may be a new strategy for individualizing the treatment of chronic pain. Expand
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
TLDR
This is the first genome-wide interaction meta-analysis to report convincing evidence of age-dependent genetic effects on BMI and the sex-specificity of Genetic Investigation of Anthropometric Traits (GIANT) Consortium, and it is confirmed that this effect is related to weight change with age or the sexually dimorphism of body shape. Expand
Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: the Johnston County Osteoarthritis Project.
TLDR
It is demonstrated that in a population-based sample, serum COMP levels can distinguish an OA-affected subgroup from an unaffected subgroup and can reflect disease severity and multiple joint involvement in OA. Expand
Classification of osteoarthritis biomarkers: a proposed approach.
TLDR
The "BIPED" biomarker classification provides specific biomarker definitions with the goal of improving the ability to develop and analyze OA biomarkers, and to communicate these advances within a common framework. Expand
Development and preliminary psychometric testing of a new OA pain measure--an OARSI/OMERACT initiative.
TLDR
Preliminary psychometric testing suggests this OA pain measure is reliable and valid, and Principle components analysis demonstrated factorial complexity. Expand
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