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Autoregulation and multiple enhancers control Math1 expression in the developing nervous system.
TLDR
Two discrete sequences within the 21 kb region are identified that are conserved between mouse and human, and are sufficient for driving a lacZ reporter gene in these domains of Math1 expression in transgenic mice, suggesting that a common regulatory mechanism controls these apparently unrelated domains of expression. Expand
Progenitors of dorsal commissural interneurons are defined by MATH1 expression.
TLDR
MATH1 expression in a differentiating population of neuronal precursors in the dorsal neural tube that appear to give rise specifically to dorsal commissural interneurons is demonstrated. Expand
Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells.
TLDR
The data support the idea that helix-loop-helix proteins may represent an evolutionarily conserved family of cell-type determination genes, of which MASH1 is the first neural-specific member identified in vertebrates. Expand
Mitochondrial role in cell aging
TLDR
The fine structural and biochemical data support the concept that the mitochondria of fixed postmitotic cells may be the site of intrinsic aging because of the attack by free radicals and lipid peroxides originating in the organelles as a by-product of oxygen reduction during respiration. Expand
Defects in thalamocortical axon pathfinding correlate with altered cell domains in Mash-1-deficient mice.
TLDR
It is demonstrated that Mash-1 is required for the normal development of cell domains that in turn are required for normal TCA pathfinding, and the hypothesis that ventral telencephalic neurons and their axons guide TCAs through ventral thalamus and into ventral Telencephalon is supported. Expand
Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells
TLDR
It is concluded that in the retina, BDNF affects only the survival of ganglion cells in vitro by a direct action on these cells. Expand
Effects of Early Visual Experience and Diurnal Rhythms on BDNF mRNA and Protein Levels in the Visual System, Hippocampus, and Cerebellum
TLDR
It is reported that rearing in constant light or DR alters BDNF mRNA and protein levels in the retina, superior colliculus, V1, hippocampus, HIPP, and cerebellum, although the changes in mRNA andprotein are not always correlated. Expand
Muscle creatine kinase sequence elements regulating skeletal and cardiac muscle expression in transgenic mice.
TLDR
Several regions of the mouse MCK gene that are responsible for tissue-specific expression in transgenic mice are identified and a complex set of cis-acting sequences that have differential effects on MCK expression in skeletal and cardiac muscle are revealed. Expand
Overexpression of Brain-Derived Neurotrophic Factor Enhances Sensory Innervation and Selectively Increases Neuron Number
TLDR
Data indicate that skin-derived BDNF does not enhance survival of cutaneous sensory neurons, although it does promote neurite innervation of specific sites and sensory end organs of the skin. Expand
The muscle creatine kinase gene is regulated by multiple upstream elements, including a muscle-specific enhancer.
TLDR
Comparisons of viral and cellular enhancer sequences with the mouse MCK enhancer revealed some similarities to essential regions of the simian virus 40 enhancer as well as to a region of the immunoglobulin heavy-chain enhancer, which has been implicated in tissue-specific protein binding. Expand
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