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$l_{0}$ Norm Constraint LMS Algorithm for Sparse System Identification
TLDR
In order to improve the performance of least mean square (LMS) based system identification of sparse systems, a new adaptive algorithm is proposed which utilizes the sparsity property of such systems. Expand
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Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
Kinase inhibitors have limited success in cancer treatment because tumors circumvent their action. Using a quantitative proteomics approach, we assessed kinome activity in response to MEK inhibitionExpand
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A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
Protein lysine methyltransferases G9a and GLP modulate the transcriptional repression of a variety of genes via dimethylation of Lys9 on histone H3 (H3K9me2) as well as dimethylation of non-histoneExpand
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Inhibition of Lapatinib-Induced Kinome Reprogramming in ERBB2-Positive Breast Cancer by Targeting BET Family Bromodomains.
Therapeutics that target ERBB2, such as lapatinib, often provide initial clinical benefit, but resistance frequently develops. Adaptive responses leading to lapatinib resistance involve reprogrammingExpand
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Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
  • F. Liu, X. Chen, +17 authors J. Jin
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 24 December 2009
SAR exploration of the 2,4-diamino-6,7-dimethoxyquinazoline template led to the discovery of 8 (UNC0224) as a potent and selective G9a inhibitor. A high resolution X-ray crystal structure of theExpand
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Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia.
Enhancer of zeste homolog 2 (EZH2) and related EZH1 control gene expression and promote tumorigenesis via methylating histone H3 at lysine 27 (H3K27). These methyltransferases are ideal therapeuticExpand
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Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons
Angelman syndrome is a severe neurodevelopmental disorder caused by deletion or mutation of the maternal allele of the ubiquitin protein ligase E3A (UBE3A). In neurons, the paternal allele of UBE3AExpand
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A Stochastic Gradient Approach on Compressive Sensing Signal Reconstruction Based on Adaptive Filtering Framework
TLDR
We propose a stochastic gradient-based adaptive filtering framework, which is commonly used in system identification, to solve sparse signal reconstruction problem. Expand
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The promise and peril of chemical probes.
TLDR
We will create a community-driven wiki resource to improve quality and convey current best practice.Chemical probes are powerful reagents with increasing impacts on biomedical research. Expand
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Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
TLDR
We identify the benzodiazepine drug lorazepam as a non-selective GPR68 positive allosteric modulator. Expand
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