Synthesis and Structure Determination of Kahalalide F1,2
- À. López-Macià, J. Jimenez, M. Royo, A. Giralt, F. Albericio
- 27 October 2001
Chemistry, Biology
HPLC, high-field NMR, and biological activity studies showed that the correct solid-phase synthetic approach to Kahalalide F was reported, with good results in clinical trials for treatment of prostate cancer.
Abbreviated nomenclature for cyclic and branched homo- and hetero-detic peptides.
- J. Spengler, J. Jimenez, K. Burger, E. Giralt, F. Albericio
- 1 June 2005
Chemistry, Biology
Journal of Peptide Research
The aim of this contribution is to offer an unambiguous and general nomenclature system that enables researchers to represent all cyclic and branched homo- and hetero-detic peptides in a coherent manner in one-line text - as long as their as constituents can be represented in (three)-letter codes.
Structure-activity relationship of kahalalide F synthetic analogues.
- J. Jimenez, À. López-Macià, F. Albericio
- 1 August 2008
Chemistry, Biology
Journal of Medicinal Chemistry
The solid phase synthesis of 132 novel analogues of kahalalide F revealed that KF is highly sensitive to backbone stereotopical modification but not to side chain size modification, suggesting that this compound has a defined conformational structure.
Kahalalide B. Synthesis of a natural cyclodepsipeptide
- À. López-Macià, J. Jimenez, M. Royo, E. Giralt, F. Albericio
- 9 December 2000
Chemistry
Synthesis and structure determination of kahalalide F (1,2).
- À. López-Macià, J. Jimenez, M. Royo, E. Giralt, F. Albericio
- 2001
Chemistry
Journal of the American Chemical Society
HPLC, high-field NMR, and biological activity studies showed that the correct stereochemistry of the natural product is that proposed by Rinehart et al, whereas the stereochemistry proposed by Scheuer et al. is that of a biologically less active diastereoisomer.
Synthesis of peptides containing α, β-didehydroamino acids. Scope and limitations
- J. Jimenez, N. Bayó, F. Albericio
- 1 March 2002
Chemistry, Biology
Letters in peptide science
A reappraisal of the use of the water-soluble carbodiimide/CuCl method for the preparation of this kind of peptide in both solution and solid-phase modes is reported and some side reactions encountered during the process are described.
Tentoxin as a scaffold for drug discovery. Total solid-phase synthesis of tentoxin and a library of analogues.
- J. Jimenez, Bibiana Chavarría, À. López-Macià, M. Royo, E. Giralt, F. Albericio
- 9 May 2003
Chemistry, Biology
Organic Letters
A solid-phase method for the synthesis of tentoxin has been developed and should be applicable to the generation of further libraries that have the tentoxin scaffold structure, as well as other structures containing N-alkylated didehydroamino acids.
Solid-phase synthesis of the cyclic lipononadepsipeptide [N-Mst(Ser1), d-Ser4, L-Thr6, L-Asp8, L-Thr9]syringotoxin.
- N. Bayó, J. Jimenez, L. Rivas, E. Nicolás, F. Albericio
- 3 March 2003
Chemistry, Biology
Chemistry
An optimized solid-phase strategy for the preparation of the cyclic lipononadepsipeptide is reported, based on the use of a mild orthogonal protection scheme and the incorporation of the nonproteinogenic amino acid (Z)-Dhb into the peptide chain as the dipeptide Fmoc-Thr(tBu)-(Z)-dhb-OH.
Solid‐Phase Synthesis of Peptides Containing α,β‐Didehydroamino Acids
- M. Royo, J. Jimenez, À. López-Macià, E. Giralt, F. Albericio
- 2001
Chemistry, Biology
A mild and convenient method for the preparation of peptides containing α,β-didehydroamino acids, where solid-phase techniques are used both for elongation of the peptide chain and formation of the double bond.
Therapeutic Hotline: Topical glycopyrrolate: a successful treatment for craniofacial hyperhidrosis and eccrine hidrocystomas.
- G. Saucedo, J. Jimenez, R. Puya, Antonio Bujaldón
- 2010
Medicine
The successful treatment of multiple center facial eccrine hidrocystomas associated with craniofacial hyperhidrosis with 0.5% glycopyrrolate aqueous solution applied locally for 1 week is described.
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