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Deciphering the genetic determinants for aerobic nicotinic acid degradation: The nic cluster from Pseudomonas putida KT2440
TLDR
A gene cluster (nic genes) from Pseudomonas putida KT2440 is characterized, allowing exploration of the existence of orthologous gene clusters in saprophytic bacteria and some pathogens, and it provides a framework to develop new biotechnological processes for detoxification/biotransformation of N-heterocyclic aromatic compounds. Expand
Short-Term Monotherapy in HIV-Infected Patients with a Virus Entry Inhibitor Against the gp41 Fusion Peptide
TLDR
It may be difficult for HIV-1 to develop resistance to VIR-576 because the fusion peptide is highly conserved and hardly tolerates changes without loss of function, and prospects for a new class of drugs that prevent virus particles from anchoring to and infecting host cells are offered. Expand
From lectin structure to functional glycomics: principles of the sugar code.
TLDR
The strategic combination of methods to monitor distinct aspects of the lectin-glycan interplay offers a promising perspective to answer the central question of how the exquisite target specificity of endogenous lectins for certain cellular glycans can be explained. Expand
Lignin Composition and Structure in Young versus Adult Eucalyptus globulus Plants1
TLDR
The data indicated that p-hydroxyphenyl and guaiacyl units are deposited at the earlier stages, whereas the woods are enriched in syringyl (S) lignin during late lignification, and resinols are the most important nonether linkages. Expand
Analysis of lignin–carbohydrate and lignin–lignin linkages after hydrolase treatment of xylan–lignin, glucomannan–lignin and glucan–lignin complexes from spruce wood
TLDR
The study provides evidence for the existence of structurally different lignins associated to hemicelluloses and cellulose in spruce wood and, at the same time, offers information on some of the chemical linkages between the above polymers. Expand
Molecular Characterization of the Gallate Dioxygenase from Pseudomonas putida KT2440
TLDR
The galA gene product from Pseudomonas putida KT2440 is characterized, a ring-cleavage dioxygenase that acts specifically on gallate to produce 4-oxalomesaconate and points to the existence of a new pathway that is devoted to the catabolism of gallic acid and that remained unknown in the paradigmatic P. putidaKT2440 strain. Expand
Structural Requirements for Multimerization of the Pathogen Receptor Dendritic Cell-specific ICAM3-grabbing Non-integrin (CD209) on the Cell Surface*
TLDR
The results demonstrate that the presence of allelic variants or a high level of expression of neck domain splicing isoforms might influence the presence and stability of DC-SIGN multimers on the cell surface, thus providing a molecular explanation for the correlation betweenDC-SIGN polymorphisms and altered susceptibility to HIV-1 and other pathogens. Expand
Chemistry of lipid A: at the heart of innate immunity.
TLDR
The chemical aspects regarding lipid A and its role in innate immunity are described and discussed, from the (bio)synthesis, isolation and characterization to the molecular recognition at the atomic level. Expand
5‐hydroxymethylfurfural conversion by fungal aryl‐alcohol oxidase and unspecific peroxygenase
TLDR
The ability of fungal aryl‐alcohol oxidase (AAO) to oxidize HMF is reported here for the first time, resulting in almost complete conversion into 2,5‐formylfurancarboxylic acid (FFCA) in a few hours. Expand
Production of Galacto-oligosaccharides by the β-Galactosidase from Kluyveromyces lactis : comparative analysis of permeabilized cells versus soluble enzyme.
TLDR
Results were correlated with the higher stability of β-galactosidase when permeabilized whole cells were used, and the typical profile with a maximum GOS concentration followed by partial hydrolysis of the newly formed oligosaccharides was not observed with the soluble enzymes. Expand
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