• Publications
  • Influence
Pharmacokinetics of theophylline; Application to adjustment of the clinical dose of aminophylline
TLDR
Serial airway resistances in 7 asthmatic patients following a large single oral dose of aminophylline indicated that the minimum theophyllines required for maximum bronchodilator effect ranged between eight and 20 µg per milliliter, suggesting wide variations in metabolism appear to be chiefly responsible.
Aerosol delivery from a metered-dose inhaler during mechanical ventilation. An in vitro model.
TLDR
It is concluded that in addition to other known factors such as dose, type of spacer, and its position the technique of administering MDIs in mechanically ventilated patients markedly influences lower respiratory tract aerosol delivery.
Dose-response to bronchodilator delivered by metered-dose inhaler in ventilator-supported patients.
TLDR
Four puffs of albuterol given by a MDI and spacer provided the best combination of bronchodilator effect and safety in stable mechanically ventilated patients with COPD.
The effect of nitroglycerin in gas exchange on chronic obstructive pulmonary disease.
TLDR
It is recommended that in patients receiving nitroglycerin who have obstructive airway disease, attention be directed toward the effect on arterial blood gases, as it is postulated that decreased O2 transport plus hypocapnia were a sufficient stimulus to raise blood lactate.
A study of the renal clearances, metabolic inactivation rates, and serum fall-off interaction of isoniazid and paraminosalicylic acid in man.
TLDR
The present study is concerned with certain pharmacologic parameters which remain to be characterized before the conclusion can be safely drawn that isoniazid inactivation differences are indeed being compared, and there has been some speculation about the nature of interaction of their acetylation pathways.
Serum albuterol levels in mechanically ventilated patients and healthy subjects after metered-dose inhaler administration.
TLDR
Serum levels reliably assess lower respiratory tract deposition of albuterol, and show that MDIs are more efficient for aerosol delivery in mechanically ventilated patients than was previously reported in studies using radiolabeled aerosols.
MULTICENTRE EVALUATION OF DISPOSABLE VISUAL MEASURING DEVICE TO ASSAY THEOPHYLLINE FROM CAPILLARY BLOOD SAMPLE
TLDR
This disposable device for theophylline monitoring, which can be done within 15 min at the patient's side without instruments, is sufficiently accurate to replace laboratory analysis for routine therapeutic drug monitoring.
What role for theophylline?
TLDR
Inhaled corticosteroids do not eliminate entirely the need for bronchodilators, however, nor do they fully normalise airway responsiveness, so addition of long acting P2 agonists reduces residual bronchospasm and improves nocturnal symptoms and sleep quality in most patients.
Reassessing the Therapeutic Range for Theophylline on Laboratory Report Forms: Another Viewpoint
  • J. Jenne
  • Medicine
    Pharmacotherapy
  • 12 November 1993
TLDR
John Jenne established that the rate of theophylline metabolism varies widely among patients receiving the same dosage; those with rapid metabolism achieved significantly lower blood levels than those with slow metabolism.
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