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The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss.
TLDR
These findings indicate that the GLP-1R on POMC/CART-expressing ARC neurons likely mediates liraglutide-induced weight loss. Expand
The use of pigs in neuroscience: Modeling brain disorders
TLDR
The present paper focuses on evaluating the potential for modeling symptoms, phenomena or constructs of human brain diseases in pigs, the neuropsychiatric disorders in particular. Expand
Validation of in vitro probabilistic tractography
TLDR
It is concluded that DWI tractography can be a precise tool in studying anatomical brain connectivity because of the limitations that are likely to appear in many of the current tractography methods. Expand
Identification of cannabinoid type 1 receptor expressing cocaine amphetamine-regulated transcript neurons in the rat hypothalamus and brainstem using in situ hybridization and immunohistochemistry
TLDR
It is demonstrated at the messenger level that CB1R expressing perikarya colocalize with CART expressing neurons in hypothalamic and brainstem areas known to be important in appetite control, whereas interactions at the protein level necessitate a demand for cautious interpretations of immunohistochemical results. Expand
Liraglutide: short‐lived effect on gastric emptying—long lasting effects on body weight
TLDR
This study examined the acute and chronic effects of two different GLP‐1 analogues with different pharmacokinetic profiles on GE, food intake and body weight. Expand
The postnatal development of neocortical neurons and glial cells in the Göttingen minipig and the domestic pig brain
TLDR
The domestic pig seems to be a more suitable model for evaluating the effects of developmental insults on human brain growth and neuronal development than the Göttingen minipig. Expand
Hypertrophy Dependent Doubling of L-Cells in Roux-en-Y Gastric Bypass Operated Rats
TLDR
RYGB in rats is associated with gut hypertrophy, an increase in L-cell number, but not density, and increased PYY and preproglucagon gene expression, which could explain the enhanced gut hormone dynamics seen after RYGB. Expand
The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced
TLDR
It is demonstrated that, in overtly diabetic male and female ZDF rats, prolonged exposure to GLP-1 receptor agonists does not affect biochemical or histopathological markers of pancreatitis, and whereas both exenatide and liraglutide increase β-cell mass, they have no effect on the exocrine pancreas. Expand
Assessment of in vivo MR imaging compared to physical sections in vitro—A quantitative study of brain volumes using stereology
TLDR
The study demonstrates that quantitative MRI is susceptible to observer dependent interpretation of images, and stereological estimates of brain volumes obtained in vivo by magnetic resonance imaging (MRI) to corresponding volumes from physical sections in vitro. Expand
Localization and phenotypic characterization of brainstem neurons activated by rimonabant and WIN55,212-2
TLDR
It is suggested that brainstem areas including ascending catetholaminergic A2/C2 neurons could play a role in rimonabant-induced inhibition of food intake by increasing c-Fos protein expression in TH-positive neurons. Expand
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