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Electrical stimulation of excitable tissue: design of efficacious and safe protocols
The physical basis for electrical stimulation of excitable tissue, as used by electrophysiological researchers and clinicians in functional electrical stimulation, is presented with emphasis on theExpand
Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation
It is proposed that interneuron network oscillations, in conjunction with intrinsic membrane resonances and long-loop (such as thalamocortical) interactions, contribute to 40-Hz rhythms in vivo. Expand
Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro
It is reported that high-frequency network oscillations are present in rat brain slices in vitro, occurring as a brief series of repetitive population spikes at 150–200 Hz in all hippocampal principal cell layers. Expand
Nonsynaptic modulation of neuronal activity in the brain: electric currents and extracellular ions.
  • J. Jefferys
  • Biology, Medicine
  • Physiological reviews
  • 1 October 1995
Field effects and ion fluctuations probably have modest effects during physiological activity but have a significant impact on epileptic seizures, and can sustain them in the absence of synaptic transmission. Expand
Effects of uniform extracellular DC electric fields on excitability in rat hippocampal slices in vitro
It is demonstrated that DC fields can modulate neuronal excitability in a time‐dependent manner, with no clear threshold, as a result of interactions between neuronal compartments, the non‐linear properties of the cell membrane, and effects on afferents. Expand
Sensitivity of coherent oscillations in rat hippocampus to AC electric fields
These threshold fields correspond to changes in somatic potential of ∼70 μV, below membrane potential noise levels for neurons, demonstrating the emergent properties of neuronal networks can be more sensitive than measurable effects in single neurons. Expand
Prion protein is necessary for normal synaptic function
It is argued that loss of function of PrPc may contribute to the early synaptic loss3 and neuronal degeneration seen in Creutzfeldt–Jakob disease and scrapie and bovine spongiform encephalopathy in animals. Expand
A mechanism for generation of long-range synchronous fast oscillations in the cortex
It is shown that in rat hippocampal slices interneurons do indeed fire spike doublets under conditions in which gamma oscillations are synchronized over several millimetres, whereas they fire single spikes under other conditions. Expand
A branching dendritic model of a rodent CA3 pyramidal neurone.
It is concluded that active dendritic currents are critical for regulation of the electrical output of CA3 pyramidal neurones and might be controlled in individual dendrites independently of action potential outputs, an effect of possible importance for synaptic plasticity. Expand
Post‐natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration
It is shown that acute depletion ofPrP does not affect neuronal survival in this model, ruling out loss of PrP function as a pathogenic mechanism in prion disease and validating therapeutic approaches targeting PrP. Expand