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  • Influence
QuPath: Open source software for digital pathology image analysis
TLDR
QuPath provides researchers with powerful batch-processing and scripting functionality, and an extensible platform with which to develop and share new algorithms to analyze complex tissue images, making it suitable for a wide range of additional image analysis applications across biomedical research.
Human papillomavirus related head and neck cancer survival: a systematic review and meta-analysis.
TLDR
HPV-positive HNSCCs and OPSCCs patients have a significantly lower disease specific mortality and are less likely to experience progression or recurrence of their cancer than HPV-negative patients; findings which have connotations for treatment selection in these patients.
QuPath: Open source software for digital pathology image analysis
TLDR
QuPath provides researchers with powerful batch-processing and scripting functionality, and an extensible platform with which to develop and share new algorithms to analyze complex tissue images, making it suitable for a wide range of additional image analysis applications across biomedical research.
A TMA De-Arraying Method for High Throughput Biomarker Discovery in Tissue Research
TLDR
This study describes a genuine robust TMA de-arraying algorithm for the rapid identification of TMA cores from digital slides which allows the easy partition of each TMA core for further processing.
Digital pathology and image analysis in tissue biomarker research.
TLDR
The need to integrate digital image analysis data with epidemiological, clinical and genomic data in order to fully understand the relationship between genotype and phenotype and to drive discovery and the delivery of personalized medicine is discussed.
Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies
TLDR
The data show that SRCCa phenotype comprises two distinct genotypes, and the MSI+/CIMP+/BRAF V600E+/CD3+/PDL1+ hypermethylated genotype is an ideal candidate for immune checkpoint inhibitor therapy.
Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion
TLDR
It is identified that stromal fibroblasts can alter the invasive behaviour of the epithelium, and it is shown that altered expression of KGF can mediate these functions.
Identification and Validation of an Anthracycline/Cyclophosphamide–Based Chemotherapy Response Assay in Breast Cancer
TLDR
A formalin-fixed, paraffin-embedded tissue-based assay has been developed and independently validated as a predictor of response and prognosis after anthracycline/cyclophosphamide–based chemotherapy in the neoadjuvant and adjuvant settings.
Evaluation of PTGS2 Expression, PIK3CA Mutation, Aspirin Use and Colon Cancer Survival in a Population-Based Cohort Study
TLDR
Aspirin use was associated with improved survival outcomes in this population-based cohort of colon cancer patients, but this association differed according to PTGS2 expression but not PIK3CA mutation status.
HPV-Related Oropharynx Cancer in the United Kingdom: An Evolution in the Understanding of Disease Etiology.
TLDR
It is argued that the rapidly increasing incidence of OPSCC in the United Kingdom cannot be solely attributable to the influence of HPV and the parallel increase in HPV+ and HPV- cases documented warrants further investigation, so that appropriate future prevention strategies for both types of disease can be implemented.
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