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Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants.
Forty-nine methanol extracts of 37 species of Malaysian medicinal plants were investigated for their inhibitory effects on platelet-activating factor (PAF) binding to rabbit platelets, using 3H-PAFExpand
Inhibitory effect of compounds from Zingiberaceae species on human platelet aggregation.
TLDR
Curcumin was the most effective antiplatelet compound as it inhibited AA-, collagen- and ADP-induced platelet aggregation with IC(50) values of 37.5, 60.9 and 45.7 microM, respectively. Expand
Protective Effects of Labisia pumila var. alata on Biochemical and Histopathological Alterations of Cardiac Muscle Cells in Isoproterenol-Induced Myocardial Infarction Rats
TLDR
The extracts showed significant protective effects as pretreated rats showed a significant dose-dependent decrease in cardiac enzyme activities, i.e., cardiac troponin I (cTnI), creatine kinase MB isoenzyme (CK-MB), lactate dehydrogenase (LDH), alanine transaminases (ALT) and aspartate transaminase (AST), when compared with ISO-control rats. Expand
Cytotoxic and Antifungal Activities of 5-Hydroxyramulosin, a Compound Produced by an Endophytic Fungus Isolated from Cinnamomum mollisimum
TLDR
This research suggests that fungal endophytes are a good source of bioactive metabolites which have potential applications in medicine. Expand
Inhibitory effects of compounds from Zingiberaceae species on platelet activating factor receptor binding
TLDR
Ten compounds investigated for their platelet‐activating factor (PAF) antagonistic activities on rabbit platelets using 3H‐PAF as a ligand showed significant inhibitory effects, indicating that these compounds were relatively strong PAF receptor binding inhibitors. Expand
Inhibitory Effects of Phylligenin and Quebrachitol Isolated from Mitrephora vulpina on Platelet Activating Factor Receptor Binding and Platelet Aggregation
TLDR
Phylligenin showed strong dose-dependent inhibitory activity on platelet aggregation induced by AA and ADP, and was comparable to cedrol (10.2 µM), a potent PAF antagonist. Expand
Antiplatelet Aggregation and Platelet Activating Factor (PAF) Receptor Antagonistic Activities of the Essential Oils of Five Goniothalamus Species
TLDR
Nine essential oils, hydrodistilled from different parts of five Goniothalamus species, were evaluated for their ability to inhibit platelet aggregation in human whole blood using an electrical impedance method and their inhibitory effects on platelet activating factor (PAF) receptor binding with rabbit platelets using 3H-PAF as a ligand. Expand
Raging the War Against Inflammation With Natural Products
TLDR
This review has highlighted the potential lead compounds including berberine, kaurenoic acid, α-cyperone, curcumin, and zedoarondiol for further development with the help of structure–activity relationship (SAR) studies and their current status. Expand
Inhibitory Effect of Triterpenoids from Dillenia serrata (Dilleniaceae) on Prostaglandin E2 Production and Quantitative HPLC Analysis of Its Koetjapic Acid and Betulinic Acid Contents
The crude methanol extracts and fractions of the root and stem barks of Dillenia serrata Thunb. showed 64% to 73% inhibition on the production of prostaglandin E2 (PGE2) in lipopolysaccharide-inducedExpand
Inhibitory Effects of Acetylmelodorinol, Chrysin and Polycarpol from Mitrella kentii on Prostaglandin E2 and Thromboxane B2 Production and Platelet Activating Factor Receptor Binding
TLDR
Among the compounds tested, chrysin showed a strong dose-dependent inhibitory activity on PGE2 production (IC50 value of 25.5 µM), which might be due to direct inhibition of cyclooxygenase-2 (COX-2) enzymatic activity. Expand
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