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Design, synthesis and biological evaluation of 1,3,4-oxadiazole derivatives.
3D QSAR analysis for the 21 molecules of 1,3,4-oxadiazoles was carried out by using k-Nearest Neighbor Molecular Field Analysis (kNN-MFA) combined with various selection procedures. 30 3D QSAR modelsExpand
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Multiple genus-specific markers in PCR assays improve the specificity and sensitivity of diagnosis of brucellosis in field animals.
Brucella-specific nucleotide sequences encoding the BCSP 31 kDa protein, Omp2 and the 16S rRNA were employed in three independent diagnostic PCR assays. Results of the three PCR assays on sixExpand
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Nicotinic acid hydrazones: a novel anticonvulsant pharmacophore
A series of aryl acid hydrazones of substituted aromatic acid hydrazides (D1 to D20) were synthesised and evaluated for anticonvulsant activity. Aryl acid hydrazones of Nicotinic acid hydrazide (D8,Expand
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Menthone aryl acid hydrazones: a new class of anticonvulsants.
A series of ten compounds (Compounds J(1)-J(10)) of (±) 3-menthone aryl acid hydrazone was synthesized and characterized by thin layer chromatography and spectral analysis. Synthesized compounds wereExpand
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Study of Convolvulus pluricaulis for antioxidant and anticonvulsant activity.
Convolvulus pluricaulis Choisy is a perennial wild herb commonly found on sandy & rocky areas under xerophytic conditions in northern India. It is a reputed drug of ayurveda and reported to possesExpand
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Anticonvulsant and neurotoxicity evaluation of some N(4) phenyl substituted pyridyl semicarbazones.
A series of 4-aryl substituted semicarbazones of pyridyl carbaldehyde and pyridyl methyl ketone were designed and synthesized to meet the structural requirements essential for anticonvulsantExpand
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Synthesis and screening of substituted thiosemicarbazone derivatives: an approach towards novel anticonvulsant search.
A series of thiosemicarbazones of halogen substituted benzaldehydes, benzophenone and acetophenone were synthesized using an appropriate synthetic route and characterized by thin layer chromatographyExpand
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DESIGN OF NEW PEROXISOME PROLIFERATORS GAMMA ACTIVATED RECEPTOR AGONISTS (PPARγ) VIA QSAR BASED MODELING
"Introduction: The Peroxisome proliferators-activated receptors (PPARs) are one of the nuclear fatty acid receptors, which contain a type II zinc finger DNA binding pattern and a hydrophobic ligandExpand
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Design and Evaluation of Semicarbazones and Thiosemicarbazones as Novel Anticonvulsants
A series of semicarbazones and thiosemicarbazones were designed and synthesized to meet the structural requirements essential for anticonvulsant activity. All the compounds were evaluated forExpand
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Menthone semicarbazides and thiosemicarbazides as anticonvulsant agents.
A series of novel (+/-) 3-menthone semi carbazides (1-7) and thiosemicarbazides synthesized using an appropriate synthetic route and characterized by thin layer chromatography and spectral analysis.Expand
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