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Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer.
The reverse transcriptase from human immunodeficiency virus type 1 is a heterodimer consisting of one 66-kDa and one 51-kDa subunit. The p66 subunit contains both a polymerase and an RNase H domain;Expand
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Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1.
The dipyridodiazepinone Nevirapine is a potent and highly specific inhibitor of the reverse transcriptase (RT) from human immunodeficiency virus type 1 (HIV-1). It is a member of an important classExpand
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Biological control of the grapevine dieback fungus Eutypa lata II: Influence of formulation additives and transposon mutagenesis on the antagonistic activity of Bacillus subtilis and Erwinia herbicola
The effect of different supplements on the antagonistic activity of Bacillus subtilis and Erwinia herbicola towards Eutypa lata in vitro and on autoclaved grape wood was investigated. InhibitionExpand
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The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient
Approximately 30% of human tumors characterized to date express DNA polymerase beta (pol β) variant proteins. Two of the polymerase beta cancer-associated variants are sequence-specific mutators, andExpand
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Point mutations in the West Nile virus (Flaviviridae; Flavivirus) RNA-dependent RNA polymerase alter viral fitness in a host-dependent manner in vitro and in vivo.
The West Nile virus (WNV) genome contains a single RNA-dependent RNA polymerase (RdRp) gene, which is responsible for replication of the viral genome and, as such, is an important target forExpand
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Loop II of DNA polymerase beta is important for discrimination during substrate binding.
Loop II of DNA polymerase beta (pol beta) consists of 14 amino acid residues and is highly flexible and solvent exposed. Previous research from our laboratory has shown that this loop is importantExpand
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Two DNA polymerases: HIV reverse transcriptase and the Klenow fragment of Escherichia coli DNA polymerase I.
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Loop II of DNA polymerase beta is important for polymerization activity and fidelity
The accurate replication and transmission of genetic information is critical in the life of an organism. During its entire lifespan, the genetic information is constantly under attack from endogenousExpand
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Residues Arg283, Arg285, and Ile287 in the Nucleotide Binding Pocket of Bovine Viral Diarrhea Virus NS5B RNA Polymerase Affect Catalysis and Fidelity
ABSTRACT Residues Arg283, Arg285, and Ile287 are highly conserved amino acids in bovine viral diarrhea virus RNA polymerase (BVDV RdRp) and RdRps from related positive-strand RNA viruses. This motifExpand
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