J. Jacoby

Publications13
h-index11
Citations524
Highly Influential Citations12
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Nocturnal myoclonus and nocturnal myoclonic activity in the normal population.
TLDR
The prevalence of nocturnal myoclonus was slightly higher in men than in women and positively and significantly correlated with increasing age and no relationship was found between the presence of NM or NMA and weight, smoking, or the consumption of caffeinated beverages.
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Quazepam and flurazepam: Long‐term use and extended withdrawal
TLDR
The data suggest that the optimal dose of quazepam is 15 mg, and some loss of effectiveness was noted during long‐term use of both doses of quzepam and, to a lesser extent, of flurazepams.
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Nocturnal sleep and wakefulness: effects of age and sex in normal sleepers.
TLDR
Sleep in men was characterized by a higher number of nocturnal awakenings, and in elderly men by a longer final awakening; however, other parameters of sleep efficiency did not differ considerably between the sexes.
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Dose‐response studies of quazepam
TLDR
The efficacy and comparatively less severe side effects of the 7.5‐and 15‐mg doses of quazepam suggest that these doses may be optimal when the drug is considered for the adjunctive treatment of insomnia.
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Quazepam and temazepam: Effects of short‐ and intermediate‐term use and withdrawal
TLDR
Although temazepam was effective for maintaining sleep with short‐term use, there was rapid development of tolerance for this effect with intermediate‐ term use, and quazEPam had carryover effectiveness.
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Rebound Insomnia and Elimination Half‐Life: Assessment of Individual Subject Response
TLDR
Previous reports using group mean values that demonstrate a frequent, immediate, and intense degree of rebound insomnia following abrupt withdrawal of relatively rapidly eliminated hypnotic drugs and an infrequent, delayed, and milder degree of sleep difficulty following withdrawal of slowly eliminated drugs are confirmed.
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Lorazepam—Efficacy, side effects, and rebound phenomena
  • M. Scharf, J. Jacoby
  • Psychology, Medicine
    Clinical pharmacology and therapeutics
  • 1 February 1982
TLDR
The results suggest that while 4 mg lorazepam may be effective in inducing and maintaining sleep, this dose induces clinically significant side effects that are followed by consistent rebound phenomena after withdrawal.
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Sleep apneic activity in older healthy subjects.
TLDR
In both age groups, sleep apneic activity (SAA) was slightly more prevalent in males than females and was not significantly heavier than those without SAA but were so when compared with the younger subjects with SAA.
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Sleep apneic activity in a normal population.
TLDR
SAA was positively and significantly correlated with increasing age, however, relative severity, as judged by the mean number of events and the duration of events, showed no consistent pattern in relation to age.
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Lorazepam: effects on sleep and withdrawal phenomena.
TLDR
There was a marked and significant worsening of sleep above baseline levels (rebound insomnia) on the third night as well as significant increases in tension and anxiety the next day following drug withdrawal.
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