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Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic.
Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies
- Karen Kleberg, J. Jacobsen, A. Müllertz
- BiologyThe Journal of pharmacy and pharmacology
- 1 November 2010
Objectives Based on the knowledge of human intestinal fluids, compositions of biorelevant media and their impact on solubility, dissolution and permeability studies of poorly soluble drug compounds…
TR146 cells grown on filters as a model for human buccal epithelium: I. Morphology, growth, barrier properties, and permeability
Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80.
Effect of a local anesthetic lozenge in relief of symptoms in burning mouth syndrome.
The results indicate that the bupivacaine lozenge offers a novel therapeutic modality to patients with BMS, although without alleviating effect on the associated symptoms, taste alterations, and xerostomia.
Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS.
Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: assessment of cell viability, monolayer integrity and transport of a poorly…
Filter-grown TR146 cells as an in vitro model of human buccal epithelial permeability.
The results indicate that a submerged filter-grown TR146 cell culture at day 23 of culture has the potential to model the human buccal epithelial barrier for permeation of drugs.
Buccal iontophoretic delivery of atenolol.HCl employing a new in vitro three-chamber permeation cell.
- J. Jacobsen
- Biology, MedicineJournal of controlled release : official journal…
- 29 January 2001