J. Jacobsen

Publications81
h-index27
Citations1,960
Highly Influential Citations54
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Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic.
Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies
Objectives  Based on the knowledge of human intestinal fluids, compositions of biorelevant media and their impact on solubility, dissolution and permeability studies of poorly soluble drug compounds…
TR146 cells grown on filters as a model for human buccal epithelium: I. Morphology, growth, barrier properties, and permeability
Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80.
Effect of a local anesthetic lozenge in relief of symptoms in burning mouth syndrome.
TLDR
The results indicate that the bupivacaine lozenge offers a novel therapeutic modality to patients with BMS, although without alleviating effect on the associated symptoms, taste alterations, and xerostomia.
Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS.
Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: assessment of cell viability, monolayer integrity and transport of a poorly…
Filter-grown TR146 cells as an in vitro model of human buccal epithelial permeability.
TLDR
The results indicate that a submerged filter-grown TR146 cell culture at day 23 of culture has the potential to model the human buccal epithelial barrier for permeation of drugs.
Buccal iontophoretic delivery of atenolol.HCl employing a new in vitro three-chamber permeation cell.
  • J. Jacobsen
  • Biology, Medicine
    Journal of controlled release : official journal…
  • 29 January 2001
Development of an ex vivo retention model simulating bioadhesion in the oral cavity using human saliva and physiologically relevant irrigation media.
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