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- Publications
- Influence
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity,…
- P. Godoy, N. Hewitt, +90 authors J. Hengstler
- Biology, Medicine
- Archives of Toxicology
- 23 August 2013
This review encompasses the most important advances in liver functions and hepatotoxicity and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, zonated lobules,… Expand
Cellular imaging predictions of clinical drug-induced liver injury.
- J. J. Xu, Peter V. Henstock, M. Dunn, A. Smith, J. Chabot, D. de Graaf
- Medicine
- Toxicological sciences : an official journal of…
- 1 September 2008
Drug-induced liver injury (DILI) is the most common adverse event causing drug nonapprovals and drug withdrawals. Using drugs as test agents and measuring a panel of cellular phenotypes that are… Expand
Genetic relationship of populations in China.
- J. Chu, W. Huang, +11 authors L. Jin
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 29 September 1998
Despite the fact that the continuity of morphology of fossil specimens of modern humans found in China has repeatedly challenged the Out-of-Africa hypothesis, Chinese populations are underrepresented… Expand
DIFFERENTIAL INTERACTION OF 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE INHIBITORS WITH ABCB1, ABCC2, AND OATP1B1
- Cuiping Chen, Rouchelle J Mireles, +4 authors T. Smolarek
- Chemistry, Medicine
- Drug Metabolism and Disposition
- 1 April 2005
The present study examined the interaction of four 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (atorvastatin, lovastatin, and simvastatin in acid and lactone forms, and pravastatin in… Expand
Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.
- Benjamin D. Cosgrove, Bracken M. King, +8 authors D. Lauffenburger
- Medicine
- Toxicology and applied pharmacology
- 1 June 2009
Idiosyncratic drug hepatotoxicity represents a major problem in drug development due to inadequacy of current preclinical screening assays, but recently established rodent models utilizing bacterial… Expand
In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone.
- J. Dykens, Joseph D. Jamieson, +5 authors Y. Will
- Chemistry, Medicine
- Toxicological sciences : an official journal of…
- 1 June 2008
Mitochondrial toxicity is increasingly implicated in a host of drug-induced organ toxicities, including hepatotoxicity. Nefazodone was withdrawn from the U.S. market in 2004 due to hepatotoxicity.… Expand
Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia.
- Scott D. Campbell, S. D. de Morais, J. J. Xu
- Chemistry, Medicine
- Chemico-biological interactions
- 20 November 2004
OATP1B1 (a.k.a. OATP-C, OATP2, LST-1, or SLC21A6) is a liver-specific organic anion uptake transporter and has been shown to be a higher affinity bilirubin uptake transporter than OATP1B3. Using… Expand
Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential.
- J. J. Xu, Dolores Diaz, P. O’Brien
- Medicine
- Chemico-biological interactions
- 1 November 2004
While drug toxicity (especially hepatotoxicity) is the most frequent reason cited for withdrawal of an approved drug, no simple solution exists to adequately predict such adverse events. Simple… Expand
Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.
- B. Feng, J. J. Xu, +8 authors H. Wang
- Biology, Medicine
- Toxicological sciences : an official journal of…
- 1 April 2009
CP-724,714, a potent and selective orally active HER2 tyrosine kinase inhibitor, was discontinued from clinical development due to unexpected hepatotoxicity in cancer patients. Based on the clinical… Expand
Comparisons between in vitro whole cell imaging and in vivo zebrafish-based approaches for identifying potential human hepatotoxicants earlier in pharmaceutical development
- A. Hill, N. Mesens, M. Steemans, J. J. Xu, M. Aleo
- Medicine
- Drug metabolism reviews
- 30 January 2012
Drug-induced liver injury (DILI) is a major cause of attrition during both the early and later stages of the drug development and marketing process. Reducing or eliminating drug-induced severe liver… Expand