Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
- R. Parker, B. Pearce, R. Clark, D. Gordon, J. J. Wright
- Biology, ChemistryJournal of Biological Chemistry
- 25 May 1993
Characterization of CCX282-B, an Orally Bioavailable Antagonist of the CCR9 Chemokine Receptor, for Treatment of Inflammatory Bowel Disease
- M. Walters, Yu Wang, T. Schall
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 October 2010
Inhibition of CCR9 with CCX282-B results in normalization of Crohn's disease such as histopathology associated with the TNFΔARE mice, and analysis of the plasma level of drug associated with this improvement provides an understanding of the pharmacokinetic/pharmacodynamic relationship for C CR9 antagonists in the treatment of intestinal inflammation.
Hypocholesterolemic activity of synthetic and natural tocotrienols.
- B. Pearce, R. Parker, M. E. Deason, A. Qureshi, J. J. Wright
- Biology, ChemistryJournal of Medicinal Chemistry
- 2 October 1992
The synthetic (racemic) and natural tocotrienols exhibit nearly identical cholesterol biosynthesis inhibition and HMG-CoA reductase suppression properties as demonstrated in vitro and in vivo.
Biosynthesis of terpenes and steroids. Part IV. Specific hydride shifts in the biosynthesis of lanosterol and β-amyrin
- D. Barton, G. Mellows, D. Widdowson, J. J. Wright
- Chemistry
- 1971
The hydride shifts accompanying 2,3-epoxysqualene cyclisation to lanosterol in yeast and to β-amyrin in peas have been checked using 2,3-epoxy[11,14-3H2]squalene. The results support the…
N-aminoacyl derivatives of polyene macrolide antibiotics and their esters.
- J. J. Wright, J. A. Albarella, L. R. Krepski, D. Loebenberg
- ChemistryJournal of antibiotics (Tokyo. )
- 1 July 1982
The synthesis of N-aminoacyl derivatives of polyene esters which appear to represent a significant advance in this area and are more water-soluble and less toxic than the parent polyenes, but retain their antifungal potency both in vitro and in vivo.
A potent, tissue-selective, synthetic inhibitor of HMG-CoA reductase.
- N. Balasubramanian, P. Brown, J. J. Wright
- Chemistry, MedicineJournal of Medicinal Chemistry
- 1 September 1989
La synthese et l'isolation d'un nouveau inhibiteur synthetique de HMG-CoA reductase (BMY 22089) qui est tissu-selectif, a ete accomplie apres travail chimique sur les tetrazoles alkyles. La…
1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation.
- N. Meanwell, H. Roth, E. Gillespie
- Chemistry, BiologyJournal of Medicinal Chemistry
- 1 September 1991
On the basis of platelet inhibitory properties in vitro, efficacy at preventing thrombus formation in animal models of thrombosis, and a favorable hemodynamic profile, 1,3-dihydro-7,8-dimethyl-2H- imidazo[4,5-b]quinolin-2-one (7o, BMY 20844) was selected for advancement into toxicological evaluation and clinical trial.
Studies in relation to biosynthesis. XLII. The structural elucidation and some aspects of the biosynthesis of the brevianamides-A and -E.
- A. J. Birch, J. J. Wright
- ChemistryTetrahedron
- 1970
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