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Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18
Specific chromosomal translocations found in distinct neoplasms suggest that genes that flank such breakpoints play a critical role in transformation. We have characterized the t(14;18)(q32;q21)Expand
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Hypocholesterolemic activity of synthetic and natural tocotrienols.
Tocotrienols are farnesylated benzopyran natural products that exhibit hypocholesterolemic activity in vitro and in vivo. The mechanism of their hypolipidemic action involves posttranscriptionalExpand
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A rapid and sensitive method for determination of sorafenib in human plasma using a liquid chromatography/tandem mass spectrometry assay.
  • M. Zhao, M. Rudek, +7 authors S. Baker
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical…
  • 1 February 2007
A rapid, sensitive and specific method was developed and validated using LC/MS/MS for determination of sorafenib in human plasma. Sample preparation involved a single protein precipitation step byExpand
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Plasma protein binding of sorafenib, a multi kinase inhibitor: in vitro and in cancer patients
SummarySorafenib is an orally administered multikinase inhibitor that exhibits antiangiogenic and antitumor activity. Few investigators have been able to correlate cumulative sorafenib dose or totalExpand
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Biosynthesis of terpenes and steroids. Part IV. Specific hydride shifts in the biosynthesis of lanosterol and β-amyrin
The hydride shifts accompanying 2,3-epoxysqualene cyclisation to lanosterol in yeast and to β-amyrin in peas have been checked using 2,3-epoxy[11,14-3H2]squalene. The results support theExpand
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A potent, tissue-selective, synthetic inhibitor of HMG-CoA reductase.
La synthese et l'isolation d'un nouveau inhibiteur synthetique de HMG-CoA reductase (BMY 22089) qui est tissu-selectif, a ete accomplie apres travail chimique sur les tetrazoles alkyles. LaExpand
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N-aminoacyl derivatives of polyene macrolide antibiotics and their esters.
Amphotericin B continues to be the drug of choice for the treatment of deep-seated fungal infections despite the usual accompaniment of severe toxic side-reaction and there has been considerableExpand
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1,3-Dihydro-2H-imidazo[4,5-b]quinolin-2-ones--inhibitors of blood platelet cAMP phosphodiesterase and induced aggregation.
A series of 1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one derivatives was synthesized and evaluated as inhibitors of cAMP hydrolysis by a crude human platelet phosphodiesterase preparation and asExpand
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Nonprostanoid prostacyclin mimetics. 3. Structural variations of the diphenyl heterocycle moiety.
4,5-Diphenyl-2-oxazolenonanoic acid (2) and 2-[3-[2-(4,5-diphenyl-2-oxazolyl)ethyl]phenoxy]acetic acid (3) were previously identified as nonprostanoid prostacyclin (PGI2) mimetics that inhibitExpand
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