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Structure-activity studies on acetylcholinesterase inhibition in the lycorine series of Amaryllidaceae alkaloids.
The synthesis of differentially functionalized analogs of the Amaryllidaceae alkaloid lycorine, accessed via a concise chemoselective silylation strategy, is described uncovering two of the mostExpand
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Apoptosis-inducing effects of distichamine and narciprimine, rare alkaloids of the plant family Amaryllidaceae.
Several of the Amaryllidaceae alkaloids are known for their cytotoxic properties, of which the lycorine group representatives are prominent for potent and cell line specific antiproliferativeExpand
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Cytotoxic and antimalarial alkaloids from Brunsvigia littoralis.
Four known alkaloids, lycorine (1), 1,2-di-O-acetyllycorine (2), ambelline (3), and crinine (4) were isolated from the bulbs of Brunsvigia littoralis (Amaryllidaceae). 1H- and 13C-NMR spectra of 2Expand
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Selective apoptosis-inducing activity of crinum-type Amaryllidaceae alkaloids.
The selective apoptosis-inducing activity of Amaryllidaceae alkaloids belonging to the crinane-type is reported. A mini-library of natural and synthetic crinane alkaloids was assembled. BiologicalExpand
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Antibacterial activity of crinane alkaloids from Boophone disticha (Amaryllidaceae).
ETHNOPHARMACOLOGICAL RELEVANCE Boophone disticha (Amaryllidaceae) is one of the most common bulbous plants used for medicinal purposes by the indigenous people of southern Africa. Its use as aExpand
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Isolation of narciprimine from Cyrtanthus contractus (Amaryllidaceae) and evaluation of its acetylcholinesterase inhibitory activity.
ETHNOPHARMACOLOGICAL RELEVANCE Plants of the family Amaryllidaceae are used widely in traditional medicine in South Africa. Several of these, including representatives of the genus Cyrtanthus findExpand
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Structure-activity studies on the lycorine pharmacophore: A potent inducer of apoptosis in human leukemia cells
Abstract The direct chemoselective differential functionalization of the ring-C hydroxyl groups present in the Amaryllidaceae alkaloid lycorine isExpand
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Bioactive alkaloids from Brunsvigia radulosa.
A phytochemical investigation of the bulbs of Brunsvigia radulosa yielded the new alkaloid 1-O-acetylnorpluviine, together with the known structures 1-epideacetylbowdensine, crinamine, crinine,Expand
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Determination of patulin in apple juice by high-performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry.
An HPLC-MS-MS method with selected reaction monitoring (SRM) for the determination of patulin in apple juice samples is described. Mass spectrometric detection was accomplished following atmosphericExpand
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Alkaloids from Crinum macowanii.
Eleven alkaloids have been isolated from fresh bulbs of Crinum macowanii (Amaryllidaceae). Macowine is reported here for the first time. The structure and stereochemistry of this new alkaloid as wellExpand
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