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A comparison of protein synthesis by liver parenchymal cells isolated from Fischer F344 rats of various ages
TLDR
Although protein synthesis decreased significantly from 4 to 18 months, the fidelity of protein synthesis remained constant and the types of proteins synthesized by isolated liver parenchymal cells isolated from 2- or 18-month-old rats as determined by SDS-polyacrylamide gel electrophoresis. Expand
Rates of protein synthesis by hepatocytes isolated from rats of various ages
TLDR
The rate of total protein synthesis in isolated hepatocytes was determined and is comparable to rates reported for perfused liver and liver in vivo and is approximately 64% higher than the rate of protein synthesis by hepatocytes from 18‐month‐old rats. Expand
Exploiting phosphonate chemistry in metal-mediated dearomatization: stereoselective construction of functionalized spirolactams from arene ruthenium complexes.
TLDR
An asymmetric spirocyclization was demonstrated through application of this procedure to a beta-amido phosphonate prepared from (S)-(-)-alpha-methyl benzylamine and the expected spirolactam product was obtained as a single enantiomer. Expand
Oxidative demetalation of cyclohexadienyl ruthenium(II) complexes: a net Ru-mediated dearomatization.
[reaction: see text] An experimentally simple method for the demetalation of spirocyclic cyclohexadienylruthenium(II) complexes has been developed. Treatment of an alkoxy-substituted cyclohexadienylExpand
Functionalized spiro- and fused-ring heterocycles via oxidative demetalation of cyclohexadienyl ruthenium complexes.
TLDR
The isolation of alicyclic cyclohexadienone derivatives upon demetalation constitutes completion of a Ru-mediated dearomatization process. Expand
Influence of Halide Ion and Lewis Acid in the Demetalation of a Spirolactam Cyclohexadienyl Ruthenium Complex
Demetalation of an electron-rich spirolactam-based (cyclohexadienyl)Ru(II) complex is achieved upon treatment with boron trifluoride and a source of chloride ion. The cyclohexadienyl ligand isExpand
Ruthenium-Coordinated Spirolactams via Intramolecular Nucleophilic Addition to η6-Arene Metal Complexes
Cyclohexadienyl ruthenium(II) complexes incorporating an azaspirocyclic ring system have been prepared from (η6-N-benzyl acetoacetamide)CpRu(II) precursors via an intramolecular nucleophilic aromaticExpand
Oxidative demetalation of cyclohexadienyl ruthenium(II) complexes: a net Ru-mediated dearomatization.
TLDR
An experimentally simple method for the demetalation of spirocyclic cyclohexadienylruthenium(II) complexes has been developed and these heterocyclic products are well suited for further synthetic elaboration. Expand
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