CIP2A Inhibits PP2A in Human Malignancies
- M. Junttila, P. Puustinen, J. Westermarck
- Biology, MedicineCell
- 13 July 2007
Every step of the way: integrins in cancer progression and metastasis
- Hellyeh Hamidi, J. Ivaska
- BiologyNature Reviews. Cancer
- 12 July 2018
The contribution of integrins to the different steps of cancer progression is discussed, highlighting some of the recently identified unconventional roles ofIntegrins and novel opportunities to target integrin signalling are highlighted.
Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer
- K. Vuoriluoto, H. Haugen, J. Ivaska
- 24 March 2011
It is shown that vimentin functionally contributes to EMT and is required for induction of Axl expression, and regulation of breast cancer cell migration in two- and three-dimensional matrices by vimentsin is Axl- dependent and that Axl functional contributes to lung extravasation of breast cancers cells in mice.
Novel functions of vimentin in cell adhesion, migration, and signaling.
- J. Ivaska, Hanna-Mari Pallari, J. Nevo, J. Eriksson
- BiologyExperimental Cell Research
- 10 June 2007
Integrins as biomechanical sensors of the microenvironment
- Jenny Z. Kechagia, J. Ivaska, Pere Roca-Cusachs
- Biology, Materials ScienceNature reviews. Molecular cell biology
- 10 June 2019
An overview of how integrin function is regulated from both a biochemical and a mechanical perspective, affecting integrin cell-surface availability, binding properties, activation or clustering is provided, and how this biomechanical regulation allows integrins to respond to different ECM physicochemical properties and signals.
Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of β1-integrins
- T. Pellinen, Antti Arjonen, K. Vuoriluoto, Katja Kallio, J. Fransen, J. Ivaska
- BiologyJournal of Cell Biology
- 5 June 2006
In conclusion, overexpression of Rab21 fails to induce cell adhesion via an integrin point mutant deficient in Rab21 association, which provides mechanistic insight into how integrins are targeted to intracellular compartments and how their traffic regulatescell adhesion.
PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility.
- J. Ivaska, K. Vuoriluoto, T. Huovinen, I. Izawa, M. Inagaki, P. Parker
- BiologyEMBO Journal
PKCepsilon controls the transport of endocytosed beta1-integrins to the plasma membrane regulating directional cell motility and PKC-mediated phosphorylation of vimentin is a key process in integrin traffic through the cell.
Internalization of Echovirus 1 in Caveolae
- V. Marjomäki, V. Pietiäinen, J. Heino
- BiologyJournal of Virology
- 15 February 2002
The expression of dominant negative caveolin in cells markedly inhibited EV1 infection, indicating the importance of caveolae for the viral replication cycle of EV1.
CIP2A Is Associated with Human Breast Cancer Aggressivity
- C. Côme, A. Laine, J. Westermarck
- Biology, MedicineClinical Cancer Research
- 15 August 2009
The data show that CIP2A is associated with clinical aggressivity in human breast cancer and promotes the malignant growth of breast cancer cells.
Cooperation between integrins and growth factor receptors in signaling and endocytosis.
The present knowledge about the interplay between integrins and GFRs is reviewed and recent ideas of how this collaboration may explain some previous controversies in integrin research are discussed.