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Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors
TLDR
Recent optimized procedures for CGH are described, including DNA labeling, hybridization, fluorescence microscopy, digital image analysis, data interpretation, and quality control, emphasizing those steps that are most critical. Expand
In vivo amplification of the androgen receptor gene and progression of human prostate cancer
TLDR
This work has identified a similar molecular mechanism in vivo for endocrine treatment failure in human prostate cancer which involves amplification of the androgen receptor (AR) gene. Expand
Prognostic significance of elevated cyclooxygenase-2 expression in breast cancer.
TLDR
The results indicate that elevated Cox-2 expression is more common in breast cancers with poor prognostic characteristics and is associated with an unfavorable outcome, and support efforts to initiate clinical trials on the efficacy of Cox- 2 inhibitors in adjuvant treatment of breast cancer. Expand
Inherited susceptibility to uterine leiomyomas and renal cell cancer
TLDR
It is shown that predisposition to uterine leiomyomas and papillary renal cell cancer can be inherited dominantly through the hereditaryLeiomyomatosis and renal cell cancers (HLRCC) gene. Expand
Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab.
TLDR
HER-2/neu amplification is common in the intestinal type of gastric carcinoma, and it is associated with a poor outcome, and this hypothesis deserves to be investigated in clinical trials. Expand
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity
TLDR
It is indicated that aberrant PI3K pathway signaling is strongly associated with metastasis and poor survival across carcinoma types, highlighting the enormous potential impact on patient survival that pathway inhibition could achieve. Expand
ImmunoRatio: a publicly available web application for quantitative image analysis of estrogen receptor (ER), progesterone receptor (PR), and Ki-67
TLDR
It is anticipated that free web applications, such as ImmunoRatio, will make the quantitative image analysis of ER, PR, and Ki-67 easy and straightforward in the diagnostic assessment of breast cancer specimens. Expand
Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer.
TLDR
A short course of trastuzumab administered concomitantly with docetaxel or vinorelbine is effective in women with breast cancer who have an amplified HER2/neu gene. Expand
Genetic changes in primary and recurrent prostate cancer by comparative genomic hybridization.
TLDR
The CGH results indicate that losses of several chromosomal regions are common genetic changes in primary tumors, suggesting that deletional inactivation of putative tumor suppressor genes in these chromosomal sites is likely to underlie development of prostate cancer. Expand
Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer.
TLDR
Failure of conventional androgen deprivation therapy in prostate cancer may be caused by a clonal expansion of tumor cells that are able to continue androgen-dependent growth despite of the low concentrations of serum androgens. Expand
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