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Characterization of a Human Pancreatic Carcinoid in Vitro: Morphology, Amine and Peptide Storage, and Secretion
The study of functioning human endocrine tumors has been hampered by a lack of suitable in vitro models. We have established the first permanent cell line of a human pancreatic carcinoid tumor (BON)Expand
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The Human Carcinoid Cell Line, BON
Carcinoid tumors are endocrine neoplasms derived from neuroectodermal cells (enterochromaffin cells) of the neural crest.!.? These tumors, primarily found in the gastrointestinal tract, are uncommonExpand
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Studies of growth regulation in a neuroendocrine cell line.
Studies of growth-regulation of neuroendocrine cells have been hampered by a lack of suitable in vitro models. We established and have maintained a functioning human pancreatic carcinoid cell (BON)Expand
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Colocalization of Calcitonin Gene‐Related Peptide and Somatostatin in Pancreatic Islet Cells and Inhibition of Insulin Secretion by Calcitonin Gene‐Related Peptide in the Rat
Calcitonin gene-related peptide (CGRP)- and somatostatin (SR1F)-containing cells were identified by immunocytochemical techniques in pancreatic islet cells of the rat. CGRP-containing cells wereExpand
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Receptor‐mediated autocrine growth‐stimulatory effect of 5‐hydroxytryptamine on cultured human pancreatic carcinoid cells
5‐hydroxytryptamine (5‐HT) is a mitogen for fibroblasts, vascular smooth muscle cells, renal mesangial cells, and jejunal crypt cells. The human carcinoid cell line (termed BON) that we establishedExpand
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Effect of calcitonin gene-related peptide on glucose and gastric inhibitory polypeptide-stimulated insulin release from cultured newborn and adult rat islet cells
Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide that is present in peripheral cells of islets and in nerves around and within islets. CGRP can inhibit insulin secretion in vitro andExpand
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Neurotensin Expression and Release in Human Colon Cancers
Neurotensin (NT), a distal gut peptide released by intraluminal fats, is trophic for normal small bowel and colonie mucosa. In addition, NT stimulates growth of certain colon cancers; the mechanismExpand
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Role of Bombesin on Gut Mucosal Growth
ObjectiveThe authors examined the effects of exogenous bombesin (BBS) on gut mucosal growth in chowfed rats and the mucosal regeneration after gut atrophy brought about by feeding an elemental dietExpand
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Lovastatin Inhibits Pancreatic Cancer Growth Regardless of RAS Mutation
Lovastatin, an inhibitor of the rate-limiting enzyme of cholesterol synthesis, inhibits growth of pancreatic cancer cells. A possible mechanism of this inhibition is that lovastatin inhibits theExpand
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