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Genistein, a specific inhibitor of tyrosine-specific protein kinases.
TLDR
Genistein inhibited the EGF-stimulated increase in phosphotyrosine level in A431 cells and scarcely inhibited the enzyme activities of serine- and threonine-specific protein kinases such as cAMP-dependent protein kinase, phosphorylase kinases, and the Ca2+/phospholipid-dependent enzymeprotein kinase C. Expand
Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives.
TLDR
Matairesinol (1) and harman (5) were found to inhibit HIV replication in H9 lymphocyte cells and showed potent activity with EC(50) and therapeutic index values of 0.037 microM and 210, respectively. Expand
Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents.
TLDR
Curcumin analogues, compounds 4, 20, 22, 23, and 39 have been identified as a new class of antiandrogen agents, and they could be developed into clinical trial candidates to control androgen receptor-mediated prostate cancer growth. Expand
Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents.
TLDR
Curcumin compound was the most potent analogue against several cell lines, including HOS and 1A9 (breast cancer), with ED50 values of 0.97 and <0.63 microg/mL, respectively. Expand
Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis.
TLDR
Data suggest that certain diarylheptanoids might be valuable antitumor promoters and/or chemopreventors. Expand
Chemopreventive potential of cyclic diarylheptanoids.
TLDR
The data suggest that cyclic, as well as linear, diarylheptanoids might be valuable chemopreventors. Expand
Purified protein kinase C phosphorylates microtubule-associated protein 2.
TLDR
The peptide mapping analysis indicated thatprotein kinase C and cAMP-dependent protein kinase phosphorylate MAP2 differently, raising the possibility that phosphorylation of MAP2 by activated protein kinases C may be involved in cell-surface signal transduction. Expand
A specific inhibitor for tyrosine protein kinase from Pseudomonas.
TLDR
This report describes the first isolation of genistein from fermentation broth of Pseudomonas sp. Expand
Antitumor agents 201. Cytotoxicity of harmine and beta-carboline analogs.
Twenty-six beta-carbolines were evaluated for in vitro cytotoxicity in a human tumor cell line panel. Harmine (3) showed significant activity against several cell lines including three drug-resistantExpand
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