Share This Author
Polyoxometalates--a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors.
A capillary electrophoresis method for the characterization of ecto-nucleoside triphosphate diphosphohydrolases (NTPDases) and the analysis of inhibitors by in-capillary enzymatic microreaction
- J. Iqbal, Petra Vollmayer, N. Braun, H. Zimmermann, C. Müller
- Biology, ChemistryPurinergic Signalling
- 1 December 2005
The inhibition studies revealed pronounced differences in the potency of reactive blue 2, pyridoxalphosphate-6-azophenyl-2-4-disulfonic acid, suramin, and N6-diethyl-β,γ-dibromomethylene-ATP towards the NTPDase isoforms.
A multi-DOF robotic exoskeleton interface for hand motion assistance
- J. Iqbal, N. Tsagarakis, D. Caldwell
- Computer ScienceAnnual International Conference of the IEEE…
- 1 December 2011
The design and development of a robotic exoskeleton based rehabilitation system which provides both position and force feedback sensory information which can improve the outcomes of a professional rehabilitation exercise is outlined.
A novel exoskeleton robotic system for hand rehabilitation - Conceptualization to prototyping
An open-source multi-DOF articulated robotic educational platform for autonomous object manipulation
Benzothiazinones: a novel class of adenosine receptor antagonists structurally unrelated to xanthine and adenine derivatives.
2-Acylamino-3,1-benzothiazin-4-ones represent novel scaffolds suitable for the development of potent and selective AR antagonists for each of the four receptor subtypes.
Therapeutic Potentials of Ecto‐Nucleoside Triphosphate Diphosphohydrolase, Ecto‐Nucleotide Pyrophosphatase/Phosphodiesterase, Ecto‐5′‐Nucleotidase, and Alkaline Phosphatase Inhibitors
Most recent and significant advances in field of NTPDase, NPP, AP, and e5NT inhibitors is being discussed in detail in anticipation of providing prolific leads and relevant background for research groups interested in synthesis of selective ecto‐nucleotidase inhibitors.
Development of potent and selective inhibitors of ecto-5'-nucleotidase based on an anthraquinone scaffold.
Investigations of ecto-nucleoside triphosphate diphosphate Diphosphohydrolases and the P2Y receptor subtypes showed that compound 45 exhibited the highest degree of selectivity (>150-fold), with 52 being the most potent eN inhibitor described to date.
Development of off‐line and on‐line capillary electrophoresis methods for the screening and characterization of adenosine kinase inhibitors and substrates
Dose–response curves and calculated Ki values for standard antagonists obtained by CE were in excellent agreement with data obtained by the standard radioactive assay.
Identification of novel pyrazole–rhodanine hybrid scaffolds as potent inhibitors of aldose reductase: design, synthesis, biological evaluation and molecular docking analysis
- Hina Andleeb, Yildiz Tehseen, S. J. A. Shah, I. Khan, J. Iqbal, S. Hameed
- Chemistry, Biology
- 15 August 2016
These newly discovered aldose reductase inhibitors are believed to represent valuable lead structures to further streamline the generation of candidate compounds to target a number of pathological conditions, most strikingly long-term diabetic complications.