J. Ioannidis

Publications450
h-index111
Citations59,248
Highly Influential Citations1,918
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The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration
Systematic reviews and meta-analyses are essential to summarise evidence relating to efficacy and safety of healthcare interventions accurately and reliably. The clarity and transparency of these… Expand
  • 8,490
  • 243
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration.
Systematic reviews and meta-analyses are essential to summarize evidence relating to efficacy and safety of health care interventions accurately and reliably. The clarity and transparency of these… Expand
  • 4,862
  • 227
Quantitative Synthesis in Systematic Reviews
A quantitative systematic review, or meta-analysis, uses statistical methods to combine the results of multiple studies. Meta-analyses have been done for systematic reviews of therapeutic trials,… Expand
  • 2,201
  • 88
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Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database
In an effort to pinpoint potential genetic risk factors for schizophrenia, research groups worldwide have published over 1,000 genetic association studies with largely inconsistent results. To… Expand
  • 1,006
  • 77
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 genome-wide… Expand
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  • 57
  • PDF
COVID-19 Antibody Seroprevalence in Santa Clara County, California
Background Addressing COVID-19 is a pressing health and social concern. To date, many epidemic projections and policies addressing COVID-19 have been designed without seroprevalence data to inform… Expand
  • 374
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Contradicted and initially stronger effects in highly cited clinical research.
CONTEXT Controversy and uncertainty ensue when the results of clinical research on the effectiveness of interventions are subsequently contradicted. Controversies are most prominent when high-impact… Expand
  • 844
  • 39
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An exploratory test for an excess of significant findings
Background The published clinical research literature may be distorted by the pursuit of statistically significant results. Purpose We aimed to develop a test to explore biases stemming from the… Expand
  • 395
  • 38
  • PDF
EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs
Objectives To develop recommendations for the diagnosis, prevention and treatment of neuropsychiatric systemic lupus erythematosus (NPSLE) manifestations. Methods The authors compiled questions on… Expand
  • 473
  • 32
  • PDF
Differential Effects of NOD2 Variants on Crohn's Disease Risk and Phenotype in Diverse Populations: A Metaanalysis
OBJECTIVES:Three variants of the CARD15/NOD2 gene (SNP8, SNP12, and SNP13) have been associated with Crohn's disease (CD). We assessed the impact of NOD2 variants on the CD risk across diverse… Expand
  • 461
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