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Gender differences in object location memory: A meta-analysis
TLDR
Significant gender differences in favor of females were obtained in all clusters above the age of 13, with the exception of feminine, uncommon, and gender-neutral objects. Expand
Sex differences in mental rotation: Top–down versus bottom–up processing
TLDR
Between-sex group analysis demonstrated greater activity in women than in men in dorsalmedial prefrontal and other high-order heteromodal association cortices, suggesting women performed mental rotation in an effortful, "top-down" fashion. Expand
Molecular genetics of steroid 5 alpha-reductase 2 deficiency.
TLDR
Molecular analysis of the SRD5A2 gene resulted in the identification of 18 mutations in 11 homozygote, 6 compound heterozygotes, and 4 inferred compoundheterozygotes from 23 families with 5 alpha-reductase deficiency, suggesting that the carrier frequency of mutations in the 5alpha- reductase type 2 gene may be higher than previously thought. Expand
Androgens and male physiology the syndrome of 5α-reductase-2 deficiency
TLDR
The clinical, biochemical and molecular genetic analyses of 5α-reductase-2 deficiency highlight the significance of DHT in male sexual differentiation and male pathophysiology. Expand
Steroid 5α-Reductase Deficiency in Man: An Inherited Form of Male Pseudohermaphroditism
In male pseudohermaphrodites born with ambiguity of the external genitalia but with marked virilization at puberty, biochemical evaluation reveals a marked decrease in plasma dihydrotestosteroneExpand
Comparison of the effects of the 5 alpha-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: dose-response studies.
TLDR
Results suggest that testosterone (T) can compensate for DHT to some degree at the level of the androgen receptor, despite increasingly higher doses of the antiandrogen flutamide. Expand
Bone mineral density in the complete androgen insensitivity and 5alpha-reductase-2 deficiency syndromes.
TLDR
1) Androgens are of direct importance in the development and/or maintenance of BMD; and 2) testosterone and/ or low levels of dihydrotestosterone appear to be sufficient for BMD development and-or maintenance. Expand
Androgens and male physiology the syndrome of 5alpha-reductase-2 deficiency.
TLDR
The clinical, biochemical and molecular genetic analyses of 5alpha-reductase-2 deficiency highlight the significance of DHT in male sexual differentiation and male pathophysiology. Expand
Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase.
TLDR
Molecular and genetic studies demonstrate that the gene encoding this cDNA is normal in subjects with the genetic disease steroid 5 alpha-reductase deficiency, and cDNA-encoded enzyme exhibits a neutral to basic pH optima and is much less sensitive to inhibition by the 4-aza steroid, finasteride (MK-906). Expand
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