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Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication.
OBJECTIVE Individuals with rheumatoid arthritis (RA) with or without methotrexate (MTX) medication occasionally develop lymphoproliferative disorders (MTX-LPD and non-MTX-LPD, respectively). The… Expand
MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways
The tyrosine kinase c-Src is upregulated in various human cancers, but the molecular mechanisms underlying c-Src-mediated tumor growth remain unclear. Here we examined the involvement of microRNAs in… Expand
MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression
The tyrosine kinase c-Src is upregulated in various human cancers; however, the molecular mechanisms underlying c-Src-mediated tumor progression remain unclear. Here we show that downregulation of… Expand
Prognostic Significance of CD55 Expression in Breast Cancer
Purpose: Our recent study revealed that CD55-high population in breast cancer cell line was resistant to apoptosis and formed colonies in vitro more efficiently than CD55-low population. The present… Expand
CUBIC pathology: three-dimensional imaging for pathological diagnosis
The examination of hematoxylin and eosin (H&E)-stained tissues on glass slides by conventional light microscopy is the foundation for histopathological diagnosis. However, this conventional method… Expand
Role of leucine-rich pentatricopeptide repeat motif-containing protein (LRPPRC) for anti-apoptosis and tumourigenesis in cancers.
Due to accelerated energy consumption, enhanced function of mitochondria in tumour cells compared to normal cells is prerequisite for tumour development. Leucine-rich pentatricopeptide repeat… Expand
Predictive value of MLH1 and PD-L1 expression for prognosis and response to preoperative chemotherapy in gastric cancer
BackgroundMicrosatellite instability (MSI) and programmed death-ligand 1 (PD-L1) are candidate predictors for the response to immune checkpoint inhibitors, and may predict chemotherapy sensitivity.… Expand
Plasma‐activated medium (PAM) kills human cancer‐initiating cells
- J. Ikeda, H. Tanaka, K. Ishikawa, H. Sakakita, Y. Ikehara, M. Hori
- Chemistry, Medicine
- Pathology international
- 1 January 2018
Medical non‐thermal plasma (NTP) treatments for various types of cancers have been reported. Cells with tumorigenic potential (cancer‐initiating cells; CICs) are few in number in many types of… Expand
Expression of CUB domain containing protein (CDCP1) is correlated with prognosis and survival of patients with adenocarcinoma of lung
CUB domain containing protein (CDCP1), a transmembrane protein with intracellular tyrosine residues which are phosphorylated upon activation, is supposed to be engaged in proliferative activities and… Expand
Tumorigenic potential of mononucleated small cells of Hodgkin lymphoma cell lines.
- J. Ikeda, S. Mamat, +4 authors E. Morii
- Biology, Medicine
- The American journal of pathology
- 1 December 2010
Tumor cells with tumorigenic potential are limited to a small cell population known as cancer stem cells (CSCs). CSCs yield both CSCs and non-CSCs, whereas non-CSCs do not yield CSCs. CSCs have not… Expand