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Desflurane Preconditioning Induces Time-dependent Activation of Protein Kinase C Epsilon and Extracellular Signal-regulated Kinase 1 and 2 in the Rat Heart In Vivo
- O. Toma, N. Weber, J. I. Wolter, D. Obal, B. Preckel, W. Schlack
- Medicine
- Anesthesiology
- 1 December 2004
Background:Activation of protein kinase C epsilon (PKC-&egr;) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) are important for cardioprotection by preconditioning. The present study… Expand
The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC-epsilon and p38 MAPK.
- N. Weber, O. Toma, +4 authors W. Schlack
- Medicine
- British journal of pharmacology
- 2005
Xenon is an anesthetic with minimal hemodynamic side effects, making it an ideal agent for cardiocompromised patients. We investigated if xenon induces pharmacological preconditioning (PC) of the rat… Expand
Upstream signaling of protein kinase C-epsilon in xenon-induced pharmacological preconditioning. Implication of mitochondrial adenosine triphosphate dependent potassium channels and…
- N. Weber, O. Toma, H. Damla, J. I. Wolter, W. Schlack, B. Preckel
- Chemistry, Medicine
- European journal of pharmacology
- 6 June 2006
Xenon elicits preconditioning of the myocardium via protein kinase C-epsilon. We determined the implication of (1) the mitochondrial adenosinetriphosphate dependent potassium (K(ATP)) channels and… Expand
Role of protein kinase C-epsilon (PKCepsilon) in isoflurane-induced cardioprotection.
- D. Obal, N. Weber, +7 authors W. Schlack
- Medicine
- British journal of anaesthesia
- 2005
BACKGROUND
Volatile anaesthetics precondition the heart against infarction, an effect partly mediated by activation of the epsilon isoform of protein kinase C (PKCepsilon). We investigated whether… Expand
Mechanisms of xenon‐ and isoflurane‐induced preconditioning – a potential link to the cytoskeleton via the MAPKAPK‐2/HSP27 pathway
- N. Weber, O. Toma, J. I. Wolter, N. M. Wirthle, W. Schlack, B. Preckel
- Chemistry, Medicine
- British journal of pharmacology
- 1 October 2005
We previously demonstrated that the anesthetic gas xenon exerts cardioprotection by preconditioning in vivo via activation of protein kinase C (PKC)‐ɛ and p38 mitogen‐activated protein kinase (MAPK).… Expand
extracellular signal-regulated kinase (erk1/2 Mapk) mediates desflurane-induced pharmacological preconditioning in the rat heart : a-208 in vivo : a-208
- O. Toma, N. Weber, J. I. Wolter, B. Preckel, W. Schlack
- Medicine
- 1 June 2004
The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC‐ɛ and p38 MAPK
- N. Weber, O. Toma, +4 authors W. Schlack
- Chemistry
- 1 January 2005
1 Xenon is an anesthetic with minimal hemodynamic side effects, making it an ideal agent for cardiocompromised patients. We investigated if xenon induces pharmacological preconditioning (PC) of the… Expand
Role of protein kinase C-ε (PKCε) in isoflurane-induced cardioprotection
- D. Obal, N. Weber, +7 authors W. Schlack
- Medicine, Chemistry
- 1 February 2005
Background. Volatile anaesthetics precondition the heart against infarction, an effect partly mediated by activation of the e isoform of protein kinase C (PKCe). We investigated whether… Expand
Xenon-induced pharmacological preconditioning involves activation of p38 MAPK in vivo: A-205
- N. Weber, O. Toma, J. I. Wolter, W. Schlack, B. Preckel
- Medicine
- 1 June 2004
Department of Anaesthesiology, University Clinic Duesseldorf, Duesseldorf, Germany Background and Goal of Study: We could previously show that the noble gas Xenon induces myocardial protection by… Expand