• Publications
  • Influence
Desflurane Preconditioning Induces Time-dependent Activation of Protein Kinase C Epsilon and Extracellular Signal-regulated Kinase 1 and 2 in the Rat Heart In Vivo
Background:Activation of protein kinase C epsilon (PKC-&egr;) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) are important for cardioprotection by preconditioning. The present studyExpand
  • 92
  • 4
  • PDF
The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC-epsilon and p38 MAPK.
Xenon is an anesthetic with minimal hemodynamic side effects, making it an ideal agent for cardiocompromised patients. We investigated if xenon induces pharmacological preconditioning (PC) of the ratExpand
  • 87
  • 4
Upstream signaling of protein kinase C-epsilon in xenon-induced pharmacological preconditioning. Implication of mitochondrial adenosine triphosphate dependent potassium channels and
Xenon elicits preconditioning of the myocardium via protein kinase C-epsilon. We determined the implication of (1) the mitochondrial adenosinetriphosphate dependent potassium (K(ATP)) channels andExpand
  • 46
  • 3
Role of protein kinase C-epsilon (PKCepsilon) in isoflurane-induced cardioprotection.
BACKGROUND Volatile anaesthetics precondition the heart against infarction, an effect partly mediated by activation of the epsilon isoform of protein kinase C (PKCepsilon). We investigated whetherExpand
  • 24
  • 2
Mechanisms of xenon‐ and isoflurane‐induced preconditioning – a potential link to the cytoskeleton via the MAPKAPK‐2/HSP27 pathway
We previously demonstrated that the anesthetic gas xenon exerts cardioprotection by preconditioning in vivo via activation of protein kinase C (PKC)‐ɛ and p38 mitogen‐activated protein kinase (MAPK).Expand
  • 74
  • 1
The noble gas xenon induces pharmacological preconditioning in the rat heart in vivo via induction of PKC‐ɛ and p38 MAPK
1 Xenon is an anesthetic with minimal hemodynamic side effects, making it an ideal agent for cardiocompromised patients. We investigated if xenon induces pharmacological preconditioning (PC) of theExpand
  • 132
Role of protein kinase C-ε (PKCε) in isoflurane-induced cardioprotection
Background. Volatile anaesthetics precondition the heart against infarction, an effect partly mediated by activation of the e isoform of protein kinase C (PKCe). We investigated whetherExpand
  • 46
Xenon-induced pharmacological preconditioning involves activation of p38 MAPK in vivo: A-205
Department of Anaesthesiology, University Clinic Duesseldorf, Duesseldorf, Germany Background and Goal of Study: We could previously show that the noble gas Xenon induces myocardial protection byExpand