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The treatment-naive microbiome in new-onset Crohn's disease.
Childhood functional gastrointestinal disorders: child/adolescent.
The Rome III child and adolescent criteria represent an evolution from Rome II and should prove useful for both clinicians and researchers dealing with childhood FGIDs.
Development and validation of a pediatric Crohn's disease activity index.
It is proposed that the PCDAI could be used in multicenter projects to facilitate patient stratification by disease severity and that longitudinalPCDAI scores might provide a numerical measure of response to therapeutic regimens.
Pediatric modification of the Montreal classification for inflammatory bowel disease: The Paris classification
An international group of pediatric IBD experts met in Paris, France to develop evidence‐based consensus recommendations for a pediatric modification of the Montreal criteria, termed the Paris Classification.
Childhood functional gastrointestinal disorders
This is the first attempt at defining criteria for functional gastrointestinal disorders in infancy, childhood, and adolescence and it is suggested that clinicians refer to the criteria established for the adult population.
Development, validation, and evaluation of a pediatric ulcerative colitis activity index: a prospective multicenter study.
The rigorously developed Pediatric Ulcerative Colitis Activity Index is a noninvasive, valid, highly reliable, and responsive index with which to assess disease activity in pediatric ulcerative colitis.
Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn's disease in children.
Pediatric patients responding to an induction regimen of infliximab were more likely to be in clinical response and remission at week 54 without dose adjustment when their maintenance therapy was given every 8 weeks rather than every 12 weeks.
Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature.
- Y. Haberman, Timothy L. Tickle, L. Denson
- Medicine, BiologyThe Journal of clinical investigation
- 1 August 2014
These CD-specific host and microbe profiles identify the ileum as the primary inductive site for all forms of CD and may direct prognostic and therapeutic approaches.
Abdominal pain and irritable bowel syndrome in adolescents: a community-based study.
Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy
Single cell mapping of iCD tissues identifies a complex cellular signature of anti-TNF resistance thereby revealing novel biomarkers of treatment response and tailored therapeutic opportunities.