What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases.
- Jilly F. Evans, A. Ferguson, R. Mosley, J. Hutchinson
- Medicine, BiologyTIPS - Trends in Pharmacological Sciences
- 1 February 2008
Pharmacokinetic and Pharmacodynamic Characterization of an Oral Lysophosphatidic Acid Type 1 Receptor-Selective Antagonist
- J. Swaney, C. Chapman, D. Lorrain
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 March 2011
It is demonstrated that AM095 is an LPA1 receptor antagonist with good oral exposure and antifibrotic activity in rodent models and had no effect on normal wound healing after incisional and excisional wounding in rats.
Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor.
- C. Bonnefous, J. Vernier, T. Kamenecka
- Biology, ChemistryBioorganic & Medicinal Chemistry Letters
- 1 October 2005
Nonpeptide alphavbeta3 antagonists. 8. In vitro and in vivo evaluation of a potent alphavbeta3 antagonist for the prevention and treatment of osteoporosis.
- J. Hutchinson, W. Halczenko, M. Duggan
- Biology, ChemistryJournal of Medicinal Chemistry
- 27 September 2003
A novel strategy was employed in which a series of oxidized derivatives of 6 were prepared by exposure of 6 (or the methyl ester) to chemical oxidizing agents, which proved useful in the identification of active metabolites generated by either in vitro or in vivo metabolism.
Pharmacological Blockade of the DP2 Receptor Inhibits Cigarette Smoke-Induced Inflammation, Mucus Cell Metaplasia, and Epithelial Hyperplasia in the Mouse Lung
- K. Stebbins, A. Broadhead, D. Lorrain
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 March 2010
The data suggest that DP2 receptor antagonism may represent a novel therapy for COPD or other conditions characterized by neutrophil influx, mucus hypersecretion, and airway remodeling.
Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis
- G. Bain, K. E. Shannon, Jilly F. Evans
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 January 2017
It is demonstrated that inhibiting autotaxin is antifibrotic and may represent a novel therapeutic approach for the treatment of multiple fibrotic liver diseases, including NASH.
Therapeutic efficacy of AM156, a novel prostanoid DP2 receptor antagonist, in murine models of allergic rhinitis and house dust mite-induced pulmonary inflammation.
- K. Stebbins, A. Broadhead, D. Lorrain
- Biology, MedicineEuropean Journal of Pharmacology
- 25 July 2010
Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators.
- A. Pinkerton, R. Cube, J. Vernier
- Biology, ChemistryBioorganic & Medicinal Chemistry Letters
- 15 March 2005
Gram-negative sepsis in neonates: a nursery outbreak due to hand carriage of Citrobacter diversus.
- M. F. Parry, J. Hutchinson, N. A. Brown, C. H. Wu, L. Estreller
- MedicinePediatrics
- 1 June 1980
An outbreak of Citrobacter diversus infections occurred in a newborn nursery at a 350-bed community hospital during September and October 1978. Two infants developed sepsis and meningitis and nine…
Waterborne Legionella bozemanii and nosocomial pneumonia in immunosuppressed patients.
- M. F. Parry, L. Stampleman, J. Hutchinson, D. Folta, M. Steinberg, L. Krasnogor
- MedicineAnnals of Internal Medicine
- 1 August 1985
It is reaffirmed that excavation and construction are risk factors for the outbreak of nosocomial legionella pneumonia and is the first description of Nosocomial infection due to L. bozemanii.
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