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- Publications
- Influence
Laser Ablation Inductively Coupled Plasma Mass Spectrometry
- Robert W. Hutchinson, K. McLachlin, +5 authors J. Hutchinson
- Medicine
- Transplantation direct
- 1 September 2015
TLDR
Cutting Edge: Immunological Consequences and Trafficking of Human Regulatory Macrophages Administered to Renal Transplant Recipients
- J. Hutchinson, P. Riquelme, +20 authors F. Fändrich
- Medicine
- The Journal of Immunology
- 1 September 2011
Regulatory macrophages (M regs) were administered to two living-donor renal transplant recipients. Both patients were minimized to low-dose tacrolimus monotherapy within 24 wk of transplantation and… Expand
IFN-γ-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients.
- P. Riquelme, S. Tomiuk, +4 authors J. Hutchinson
- Biology, Medicine
- Molecular therapy : the journal of the American…
- 1 February 2013
Mouse monocytes exposed to macrophage colony-stimulating factor (M-CSF) and interferon-γ (IFN-γ) were driven to a novel suppressor phenotype. These regulatory macrophages (M regs) expressed markers… Expand
Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells.
- M. Ruhnke, H. Ungefroren, +12 authors F. Fändrich
- Biology, Medicine
- Gastroenterology
- 1 June 2005
BACKGROUND & AIMS
Adult stem cells provide a promising alternative for the treatment of diabetes mellitus and end-stage liver diseases. We evaluated the differentiation potential of human peripheral… Expand
Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study
- M. Streitz, T. Miloud, +10 authors B. Sawitzki
- Medicine
- Transplantation research
- 25 October 2013
BackgroundImmune monitoring by flow cytometry is a fast and highly informative way of studying the effects of novel therapeutics aimed at reducing transplant rejection or treating autoimmune… Expand
Hurdles in therapy with regulatory T cells
- P. Trzonkowski, R. Bacchetta, +18 authors B. Sawitzki
- Medicine
- Science Translational Medicine
- 9 September 2015
Translating regulatory T cell therapy to the clinic in Europe is making progress but has remaining challenges. Improper activation of the immune system contributes to a variety of clinical… Expand
Tracking of human cells in mice
- W. Schormann, Friedrich J. Hammersen, +16 authors J. Hengstler
- Biology, Medicine
- Histochemistry and Cell Biology
- 19 April 2008
Tracking and tracing of transplanted cells in mice is required in many fields of research. Examples are transplantation of stem cells into organs of mice to study their differentiation capacity and… Expand
Macrophages Driven to a Novel State of Activation Have Anti-Inflammatory Properties in Mice1
- Beate G. Brem‐Exner, C. Sattler, +9 authors E. Geissler
- Biology, Medicine
- The Journal of Immunology
- 1 January 2008
Recurrent episodes of inflammation underlie numerous pathologies, notably those of inflammatory bowel diseases. In this study, we describe a population of macrophages in a novel state of activation… Expand
Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function.
- Eliana Ribechini, J. Hutchinson, +18 authors M. B. Lutz
- Biology, Medicine
- Blood advances
- 13 June 2017
Granulocyte-macrophage colony-stimulating factor (GM-CSF) controls proliferation and survival of myeloid cells including monocytes. Here, we describe a time-dependent licensing process driven by… Expand
Now or never? The case for cell-based immunosuppression in kidney transplantation.
- J. Hutchinson, E. Geissler
- Medicine
- Kidney international
- 1 June 2015
By exploiting mechanisms of immunological regulation against donor alloantigen, it may be possible to reduce the dependence of kidney transplant recipients upon calcineurin inhibitor-based… Expand