J. Hutchinson

Publications111
h-index31
Citations2,932
Highly Influential Citations99
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Laser Ablation Inductively Coupled Plasma Mass Spectrometry
TLDR
LA-ICP-MS is judged to be a suitable method for assessing expression of multiple tissue antigens in solid-phase biological specimens, such as tissue sections, cytospins, or cells grown on slides, and augur well for future development of LA-ICp-MS–based bioimaging instruments for general users.
View on Wolters Kluwer
Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials
View on Elsevier
Tracking of human cells in mice
TLDR
An in situ hybridization technique is established that allows clear-cut differentiation between human and murine nuclei, based on simultaneous hybridization with human alu and mouse major satellite (mms) probes, which observed a high degree of coincidence between CM-DiI-marked cells and alu positive nuclei.
View on Springer
Cutting Edge: Immunological Consequences and Trafficking of Human Regulatory Macrophages Administered to Renal Transplant Recipients
TLDR
Regulatory macrophages warrant further study as a potential immune-conditioning therapy for use in solid-organ transplantation, and are being used to inform the design of The ONE Study, a multinational clinical trial of immunomodulatory cell therapy in renal transplantation.
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Dendritic cell immunotherapy for urological cancers using cryopreserved allogeneic tumour lysate‐pulsed cells: a phase I/II study
TLDR
To assess the feasibility, toxicity and immunogenicity of dendritic cell (DC)‐based immunotherapy in patients with advanced urological cancers, a large number of patients have received treatment with DC-based approaches.
View on Wiley
Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells.
TLDR
The ability to reprogram, expand, and differentiate peripheral blood monocytes in large quantities opens the real possibility of the clinical application of programmable cells of monocytic origin in tissue repair and organ regeneration.
View on PubMed
Hurdles in therapy with regulatory T cells
TLDR
The stance of the European Union Cooperation in Science and Technology Action BM1305, “Action to Focus and Accelerate Cell-based Tolerance-inducing Therapies—A FACTT,” is reported, which identifies hurdles hindering Treg clinical applications in Europe and provides possible solutions.
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IFN-γ-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients.
TLDR
It is concluded that mouse M regs represent a novel, phenotypically distinct subset of suppressor macrophages, and there are solid grounds to assert a near-equivalence of mouse and human M Regs.
View on PubMed
Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study
TLDR
The ONE Study panel may be adopted as a standardized method for monitoring patients in clinical trials enrolling transplant patients, particularly trials of novel tolerance promoting therapies, to facilitate fair and meaningful comparisons between trials.
View on Springer
Macrophages Driven to a Novel State of Activation Have Anti-Inflammatory Properties in Mice1
TLDR
It is concluded that IFNγ-MdC represent macrophages in a novel state of activation, possessing multiple T cell-suppressive effects with therapeutic potential for the treatment of autoimmune inflammation.
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