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P2X4R silence suppresses glioma cell growth through BDNF/TrkB/ATF4 signaling pathway
This study provides the first evidence that P2X4R plays important roles in GBM cell growth and apoptosis.
Long noncoding RNA growth arrest‐specific 5 facilitates glioma cell sensitivity to cisplatin by suppressing excessive autophagy in an mTOR‐dependent manner
Findings indicate that GAS5 may blunt the resistance of glioma cells to cisplatin by suppressing excessive autophagy through the activation of mTOR signaling, implying a promising therapeutic strategy against chemoresistance in gliomas.
Knockdown of TMPRSS3 inhibits cell proliferation, migration/invasion and induces apoptosis of glioma cells
The results indicated that knockdown of TMPRSS3 exhibited antiglioma effect, which is associated with the inactivation of the Notch signaling pathway, which suggested that TMPR SS3 might be used as a therapeutic target for glioma treatment.
Interference on cytoplasmic polyadenylation element-binding proteins affects the invasion ability of glioma stem cells.
After CPEB interference, the growth, proliferation, and invasion ofglioma stem cells were substantially inhibited, providing support for targeted therapy of glioma and for improving prognosis.
Clinical experience of microsurgery in resection of 30 cases of pineal region tumors through the modified Poppen approach
Intraoperative fistulization on the posterior wall of the third ventricule may play an active role in improving postoperative hydrocephalus and the effect of microsurgery in resection of the tumor in the pineal region through modified Poppen approach is good.
miR-148a-3p inhibits DNMT1-mediated methylation of VEGF and promotes proliferation and invasion in glioma cells via the PI3K/Akt/eNOS signaling pathway
It is indicated that miR-148a-3p down-regulates VEGF methylation by targeting DNMT1 and promotes the proliferation, invasion of the glioma cell through the PI3K/Akt/eNOS pathway.
Retracted Article: Aclarubicin regulates glioma cell growth and DNA damage through the SIRT1/PI3K/AKT signaling pathway
The results showed that treatment with different concentrations of ACR markedly impeded glioma cell survival, significantly decreased cell proliferation, and increased cell apoptosis and caspase-3 activity and ACR treatment promoted DNA damage through phosphorylation of ATM and CHK1 in U87 and U251 cells.