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Transcriptional profiling identifies upregulated genes following induction of epithelial-mesenchymal transition in squamous carcinoma cells.
During the progression of head and neck squamous cell carcinoma (HNSCC), the induction of an epithelial-mesenchymal transition (EMT) program may play a critical role in the dissemination of cellsExpand
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Bcl-2 Overexpression Induces a Partial Epithelial to Mesenchymal Transition and Promotes Squamous Carcinoma Cell Invasion and Metastasis
Evidence shows that Bcl-2 family members play a direct role in the development of some human malignancies. However, the mechanism by which Bcl-2 may influence tumor cell invasion and metastasisExpand
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Analysis of VEGF-responsive Genes Involved in the activation of endothelial cells
BackgroundIdentification of the genes and pathways associated with the activation of endothelial cells (ECs) could help uncover the role of ECs in wound healing, vascular permeability, blood brainExpand
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STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells.
The signal transducer and activator of transcription-3 (STAT3) frequently activated during tumor progression has been linked to enhanced cell growth. In squamous cell carcinoma of the head and neckExpand
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A streptococcal collagen-like protein interacts with the alpha2beta1 integrin and induces intracellular signaling.
The streptococcal collagen-like proteins Scl1 and Scl2 are prokaryotic members of a large protein family with domains containing the repeating amino acid sequence (Gly-Xaa-Yaa)(n) that form aExpand
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A Streptococcal Collagen-like Protein Interacts with the α2β1 Integrin and Induces Intracellular Signaling*
The streptococcal collagen-like proteins Scl1 and Scl2 are prokaryotic members of a large protein family with domains containing the repeating amino acid sequence (Gly-Xaa-Yaa)n that form aExpand
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Regulation of cell–cell interactions by phosphatidic acid phosphatase 2b/VCIP
We identified vascular endothelial growth factor and type I collagen inducible protein (VCIP), also known as phosphatidic acid phosphatase 2b (PAP2b), in a functional assay of angiogenesis.Expand
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Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand.
Lipid phosphate phosphohydrolase-3 (LPP3) is a cell surface protein that exhibits ectoenzyme activity. Previously, we identified human LPP3 in a functional assay of angiogenesis and showed that theExpand
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Differential Epidermal Growth Factor Receptor Signaling Regulates Anchorage-Independent Growth by Modulation of the PI3K/AKT Pathway
Tumor cells are capable of surviving loss of nutrients and anchorage in hostile microenvironments. Under these conditions, adapting to specific signaling pathways may shift the balance between growthExpand
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Lipid phosphate phosphatase-3 regulates tumor growth via β-catenin and Cyclin-D1 signaling
BackgroundThe acquisition of proliferative and invasive phenotypes is considered a hallmark of neoplastic transformation; however, the underlying mechanisms are less well known. Lipid phosphateExpand
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