• Publications
  • Influence
The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication.
BACKGROUND The probiotic Bifidobacterium longum NCC3001 normalizes anxiety-like behavior and hippocampal brain derived neurotrophic factor (BDNF) in mice with infectious colitis. Using a model ofExpand
  • 515
  • 32
Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors.
Interstitial cells of Cajal (ICC) are implicated in the regulation of gut peristalsis and are immunostained by antibodies against Kit (CD117), a tyrosine kinase receptor. Most gastrointestinalExpand
  • 518
  • 23
Assessment of gastric emptying using a low fat meal: establishment of international control values
OBJECTIVE:The diagnosis of gastroparesis implies delayed gastric emptying. The diagnostic gold standard is scintigraphy, but techniques and measured endpoints vary widely among institutions. In thisExpand
  • 300
  • 14
Regulation of slow wave frequency by IP(3)-sensitive calcium release in the murine small intestine.
Slow waves determine frequency and propagation characteristics of contractions in the small intestine, yet little is known about mechanisms of slow wave regulation. We propose a role forExpand
  • 95
  • 13
Developmental origin and kit‐dependent development of the interstitial cells of cajal in the mammalian small intestine
Interstitial cells of Cajal (ICCs) form a network of cells between the external longitudinal and circular muscle layers at the level of the Auerbach's plexus in the mammalian small intestine. TheseExpand
  • 211
  • 11
Gastric Electrical Stimulation in Intractable Symptomatic Gastroparesis
Background: The treatment of gastroparesis remains unsatisfactory despite prokinetic and anti-emetic drugs. Gastric electrical stimulation has been proposed as a therapeutic option. We have assessedExpand
  • 236
  • 10
Interstitial cells of Cajal generate a rhythmic pacemaker current
Networks of interstitial cells of Cajal embedded in the musculature of the gastrointestinal tract are involved in the generation of electrical pacemaker activity for gastrointestinal motility1,2.Expand
  • 390
  • 9
Gastrointestinal stromal tumors may originate from a subset of CD34-positive interstitial cells of Cajal.
Most gastrointestinal stromal tumors (GISTs), a subgroup of mesenchymal neoplasms of the gut wall, express both Kit (CD117) and CD34 proteins. It has been suggested that GISTs originate from orExpand
  • 156
  • 9
Gut peristalsis is governed by a multitude of cooperating mechanisms.
Peristaltic motor activity of the gut is an essential activity to sustain life. In each gut organ, a multitude of overlapping mechanisms has developed to acquire the ability of coordinatedExpand
  • 229
  • 9
Two Independent Networks of Interstitial Cells of Cajal Work Cooperatively with the Enteric Nervous System to Create Colonic Motor Patterns
Normal motility of the colon is critical for quality of life and efforts to normalize abnormal colon function have had limited success. A better understanding of control systems of colonic motilityExpand
  • 80
  • 9