J. Huidobro-Toro

Publications194
h-index38
Citations4,800
Highly Influential Citations182
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • G. Burnstock
  • 1,098 Publications • 56,904 Citations
  • R. North
  • 119 Publications • 20,568 Citations
  • A. Surprenant
  • 107 Publications • 19,886 Citations
  • S. Stojilkovic
  • 288 Publications • 10,183 Citations
  • Publications
  • Influence
Activation and Regulation of Purinergic P2X Receptor Channels
Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two transmembrane domains, and… Expand
  • 419
  • 38
  • PDF
Molecular mechanism of cGMP‐mediated smooth muscle relaxation
Contraction and relaxation of smooth muscle is a tightly regulated process involving numerous endogenous substances and their intracellular second messengers. We examine the key role of cyclic… Expand
  • 358
  • 17
P2Y1 and P2Y2 receptors are coupled to the NO/cGMP pathway to vasodilate the rat arterial mesenteric bed
To assess the role of nucleotide receptors in endothelial‐smooth muscle signalling, changes in perfusion pressure of the rat arterial mesenteric bed, the luminal output of nitric oxide (NO) and… Expand
  • 94
  • 11
ATP Released by Electrical Stimuli Elicits Calcium Transients and Gene Expression in Skeletal Muscle*
ATP released from cells is known to activate plasma membrane P2X (ionotropic) or P2Y (metabotropic) receptors. In skeletal muscle cells, depolarizing stimuli induce both a fast calcium signal… Expand
  • 127
  • 9
  • PDF
Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed
In the isolated rat mesenteric bed, the 1 min perfusion with 100 nm anandamide, a concentration that did not evoke vasorelaxation, elicited an acute release of 165.1 ± 9.2 pmol nitric oxide (NO) that… Expand
  • 101
  • 8
Zinc and Copper Modulate Differentially the P2X4 Receptor
Abstract: The rat ATP P2X4 receptor was expressed in Xenopus laevis oocytes to assess the effect of zinc and copper as possible regulators of purinergic mechanisms. ATP applied for 20 s evoked an… Expand
  • 91
  • 7
Brain lipids that induce sleep are novel modulators of 5-hydroxytrypamine receptors.
Amide derivatives of fatty acids were recently isolated from cerebrospinal fluid of sleep-deprived animals and found to induce sleep in rats. To determine which brain receptors might be sensitive to… Expand
  • 111
  • 6
  • PDF
Trace metals in the brain: allosteric modulators of ligand-gated receptor channels, the case of ATP-gated P2X receptors
Zinc and copper are indispensable trace metals for life with a recognized role as catalysts in enzyme actions. We now review evidence supporting the role of trace metals as novel allosteric… Expand
  • 42
  • 6
Kappa opioid properties of dynorphin and its peptide fragments on the guinea-pig Ileum.
  • 50
  • 3
Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5‐HT2A and 5‐HT2C receptors
The pharmacological profile of a series of (±)‐2,5‐dimethoxy‐4‐(X)‐phenylisopropylamines (X=I, Br, NO2, CH3, or H) and corresponding phenylethylamines, was determined in Xenopus laevis oocytes… Expand
  • 70
  • 3
  • PDF
...
1
2
3
4
5
...