J. Huidobro-Toro

Publications200
h-index36
Citations4,623
Highly Influential Citations154
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Activation and Regulation of Purinergic P2X Receptor Channels
TLDR
Data obtained from numerous site-directed mutagenesis experiments accumulated during the last 15 years are discussed with reference to the crystal structure, allowing a structural interpretation of the molecular basis of orthosteric and allosteric ligand actions.
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Molecular mechanism of cGMP‐mediated smooth muscle relaxation
TLDR
It is proposed that the cGMP‐induced decrease in Ca2+ sensitivity is a strategic way to achieve “active relaxation” of the smooth muscle.
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P2Y1 and P2Y2 receptors are coupled to the NO/cGMP pathway to vasodilate the rat arterial mesenteric bed
TLDR
Endothelial P2Y1 and P2y2 receptors coupled to the NO/cGMP cascade suggest that extracellular nucleotides are involved in endothelial‐smooth muscle signalling.
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ATP Released by Electrical Stimuli Elicits Calcium Transients and Gene Expression in Skeletal Muscle*
TLDR
The results suggest that nucleotides released during skeletal muscle activity through pannexin-1 hemichannels act through P2X and P2Y receptors to modulate both Ca2+ homeostasis and muscle physiology.
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Trace metals in the brain: allosteric modulators of ligand-gated receptor channels, the case of ATP-gated P2X receptors
TLDR
Evidence supporting the role of trace metals as novel allosteric modulators of ionotropic receptors: a new and fundamental physiological role for zinc and copper in neuronal and brain excitability is reviewed.
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Allosteric modulation of ATP-gated P2X receptor channels
TLDR
The focus of this review is on common and receptor-specific allosteric modulation of P2X receptors and the molecular base accounting forallosteric binding sites.
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Kappa opioid properties of dynorphin and its peptide fragments on the guinea-pig Ileum.
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Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5‐HT2A and 5‐HT2C receptors
The pharmacological profile of a series of (±)‐2,5‐dimethoxy‐4‐(X)‐phenylisopropylamines (X=I, Br, NO2, CH3, or H) and corresponding phenylethylamines, was determined in Xenopus laevis oocytes…
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Adenosine 5′‐triphosphate and neuropeptide Y are co‐transmitters in conjunction with noradrenaline in the human saphenous vein
TLDR
The present results are consistent with the working hypothesis that human sympathetic vasomotor reflexes involve the coordinated motor action of ATP, NPY, and NA acting on vascular smooth muscle cells and support the concept of sympathetic co‐transmission in the human saphenous vein.
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Clonidine‐induced nitric oxide‐dependent vasorelaxation mediated by endothelial α2‐adrenoceptor activation
TLDR
Clonidine and congeners activate endothelial α2D‐adrenoceptors coupled to the L‐arginine pathway, suggesting that the antihypertensive action of clonidine involves an endothelial vasorelaxation mediated by NO release, in addition to presynaptic mechanisms.
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