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Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators
The human X and Y chromosomes evolved from an ordinary pair of autosomes, but millions of years ago genetic decay ravaged the Y chromosome, and only three per cent of its ancestral genes survived. We… Expand
Chimpanzee and human Y chromosomes are remarkably divergent in structure and gene content
The human Y chromosome began to evolve from an autosome hundreds of millions of years ago, acquiring a sex-determining function and undergoing a series of inversions that suppressed crossing over… Expand
Conservation of Y-linked genes during human evolution revealed by comparative sequencing in chimpanzee
The human Y chromosome, transmitted clonally through males, contains far fewer genes than the sexually recombining autosome from which it evolved. The enormity of this evolutionary decline has led to… Expand
Human endogenous retrovirus K solo-LTR formation and insertional polymorphisms: implications for human and viral evolution.
- J. Hughes, J. Coffin
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 10 February 2004
Human endogenous retroviruses (HERVs) are a potential source of genetic diversity in the human genome. Although many of these elements have been inactivated over time by the accumulation of… Expand
Sequencing the Mouse Y Chromosome Reveals Convergent Gene Acquisition and Amplification on Both Sex Chromosomes
We sequenced the MSY (male-specific region of the Y chromosome) of the C57BL/6J strain of the laboratory mouse Mus musculus. In contrast to theories that Y chromosomes are heterochromatic and gene… Expand
Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes
The human X and Y chromosomes evolved from an ordinary pair of autosomes during the past 200–300 million years. The human MSY (male-specific region of Y chromosome) retains only three percent of the… Expand
Evidence for genomic rearrangements mediated by human endogenous retroviruses during primate evolution
Human endogenous retroviruses (HERVs), which are remnants of past retroviral infections of the germline cells of our ancestors, make up as much as 8% of the human genome and may even outnumber genes.… Expand
Genomics and genetics of human and primate y chromosomes.
In mammals, the Y chromosome plays the pivotal role in male sex determination and is essential for normal sperm production. Yet only three Y chromosomes have been completely sequenced to date--those… Expand
The Biology and Evolution of Mammalian Y Chromosomes.
Mammals have the oldest sex chromosome system known: the mammalian X and Y chromosomes evolved from ordinary autosomes beginning at least 180 million years ago. Despite their shared ancestry,… Expand
Human Endogenous Retroviral Elements as Indicators of Ectopic Recombination Events in the Primate Genome
HERV elements make up a significant fraction of the human genome and, as interspersed repetitive elements, have the capacity to provide substrates for ectopic recombination and gene conversion… Expand