J. Huggins

Publications32
h-index13
Citations856
Highly Influential Citations30
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Inhibition of cyclic GMP‐dependent protein kinase‐mediated effects by (Rp)‐8‐bromo‐PET‐cyclic GMPS
1 The modulation of the guanosine 3′:5′‐cyclic monophosphate (cyclic GMP)‐ and adenosine 3′:5′‐cyclic monophosphate (cyclic AMP)‐dependent protein kinase activities by the diastereomers of… Expand
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PKG-I alpha phosphorylates the alpha-subunit and upregulates reconstituted GKCa channels from tracheal smooth muscle.
Modulation of Ca(2+)-dependent K+ channel (GKCa) activities in airway smooth muscles (ASM) by guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase (PKG) is thought to play a central… Expand
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The structure and specificity of endothelin receptors: their importance in physiology and medicine.
In addition to involvement in vascular endothelium-smooth muscle communication, the secretion of and receptors for, endothelins are widely distributed. Two cloned receptor subtypes are… Expand
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A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers.
The pathology of chronic dermal ulcers is characterized by excessive proteolytic activity which degrades extracellular matrix (required for cell migration) and growth factors and their receptors. The… Expand
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Endothelins--from receptors to medicine.
Since the discovery of endothelins, peptides with exceptional vasoconstrictor potency that were originally suggested to act by causing the opening of Ca2+ channels, it has emerged that these agents… Expand
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Modulation by endothelium of the responses induced by endothelin‐1 and by some of its analogues in rat isolated aorta
1 The contractile effects of endothelin‐1 and various analogues were studied in rat isolated aortic rings. The potency order of the peptides studied was endothelin‐1 > sarafotoxin S6b >… Expand
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1H NMR and circular dichroism studies of the N-terminal domain of cyclic GMP dependent protein kinase: a leucine/isoleucine zipper.
Cyclic GMP dependent protein kinase exists as a dimer in its native form. A peptide corresponding to the dimerization domain in the N-terminal segment has been characterized by circular dichroism,… Expand
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The receptors for endothelins and their analogues in SK-N-MC neuroblastoma cells
The potency order of peptides to inhibit [125I]endothelin-1 binding and to stimulate phosphatidylinositol phosphate (PtdInsP) turnover in SK-N-MC cells was consistent with the presence of… Expand
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Sarcolemmal phospholamban is phosphorylated in isolated rat hearts perfused with isoprenaline
Phosphorylation of phospholamban in cardiac sarcolemma is implicated in the increased influx of Ca2+ through the slow calcium channel induced by catecholamines. A method is described for the… Expand
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Phospholamban is a good substrate for cyclic GMP-dependent protein kinase in vitro, but not in intact cardiac or smooth muscle.
1. Cyclic GMP-dependent protein kinase phosphorylates purified phospholamban. It also phosphorylates phospholamban present in vesicles of cardiac sarcoplasmic reticulum and smooth muscle microsomal… Expand
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