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Urolithiasis and bladder carcinogenicity of melamine in rodents.
Melamine (2,4,6-triamino-s-triazine) was administered in the diet to F344 rats or B6C3F1 mice for 13 weeks (subchronic) or for 103 weeks (chronic) to determine its toxicologic profile, includingExpand
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Carcinogenicity of 1,3-butadiene in C57BL/6 x C3H F1 mice at low exposure concentrations.
The carcinogenicity of inhaled 1,3-butadiene was evaluated in C57BL/6 x C3H F1 mice exposed to concentrations of this gas ranging from 6.25 to 625 ppm. Butadiene is a high production volume chemical,Expand
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Use of Historical Control Data in Carcinogenicity Studies in Rodents
This paper considers the use of historical control data in the evaluation of tumor incidences from carcinogenicity studies in rodents. Although the most appropriate control group for interpretativeExpand
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Fundamental Flaws of Hormesis for Public Health Decisions
Hormesis (defined operationally as low-dose stimulation, high-dose inhibition) is often used to promote the notion that while high-level exposures to toxic chemicals could be detrimental to humanExpand
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The Case for a Global Ban on Asbestos
BACKGROUND All forms of asbestos are now banned in 52 countries. Safer products have replaced many materials that once were made with it. Nonetheless, many countries still use, import, and exportExpand
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Long-term chemical carcinogenesis experiments for identifying potential human cancer hazards: collective database of the National Cancer Institute and National Toxicology Program (1976-1991).
The carcinogenicity database used for this paper originated in the late 1960s by the National Cancer Institute (NCI) and since 1978 has been continued and made more comprehensive by the NationalExpand
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Cadmium-induced Cancers in Animals and in Humans
Abstract Discovered in the early 1800s, the use of cadmium and various cadmium salts started to become industrially important near the close of the 19th century, rapidly thereafter began to flourish,Expand
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The Limits of Two-Year Bioassay Exposure Regimens for Identifying Chemical Carcinogens
Background Chemical carcinogenesis bioassays in animals have long been recognized and accepted as valid predictors of potential cancer hazards to humans. Most rodent bioassays begin several weeksExpand
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Scientific concepts, value, and significance of chemical carcinogenesis studies.
Synthetic chemicals and those naturally occurring chemicals that have be­ come 'man-made' via chemical synthesis and high volume production have only relatively recently been introduced into our wayExpand
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