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Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.
Mevinolin, a fungal metabolite, was isolated from cultures of Aspergillus terreus. The structure and absolute configuration of mevinolini and its open acid form, mevinolinic acid, were determined byExpand
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The carcinogenesis bioassay in perspective: application in identifying human cancer hazards.
The selection process for chemicals tested in the rodent carcinogenicity bioassay has been biased toward chemicals suspected of potential carcinogenicity. Results from carcinogenicity bioassays ofExpand
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Chronic effects of agar, guar gum, gum arabic, locust-bean gum, or tara gum in F344 rats and B6C3F1 mice.
Diets containing 25,000 (2.5%) or 50,000 ppm (5.0%) agar, guar gum, gum arabic, locust-bean gum or tara gum were fed to groups of 50 male and 50 female F344 rats and B6C3F1 mice for 103 wk. SeparateExpand
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Benzene-, catechol-, hydroquinone- and phenol-induced cell transformation, gene mutations, chromosome aberrations, aneuploidy, sister chromatid exchanges and unscheduled DNA synthesis in Syrian
Benzene is a human carcinogen present naturally in petroleum and gasoline. For the simultaneous assessment of benzene-induced carcinogenicity and mutagenicity, benzene and its principal metabolites,Expand
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Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA)
The International Agency for Research on Cancer (IARC) Monographs Programme identifies chemicals, drugs, mixtures, occupational exposures, lifestyles and personal habits, and physical and biologicalExpand
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Breast cancer and environmental risk factors: epidemiological and experimental findings.
Breast cancer has long been associated with reproductive hormone exposures. Recently, greater attention has been focused on environmental exposures that may be responsible for some proportion ofExpand
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The Secret History of the War on Cancer
  • J. Huff
  • Biology, Medicine
  • Environmental Health Perspectives
  • 1 February 2008
by Devra Davis New York:Basic Books, 2007. 505 pp. ISBN: 978-0-465-01566-5, $27.95 The secret of The Secret History of the War on Cancer is prevention, an acutely recognized but long neglectedExpand
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American College of Occupational and Environmental Medicine (ACOEM): A Professional Association in Service to Industry
Abstract The American College of Occupational and Environmental Medicine (ACOEM) is a professional association that represents the interests of its companyemployed physician members. Fifty years agoExpand
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Frequent p53 and H-ras Mutations in Benzene- and Ethylene Oxide-Induced Mammary Gland Carcinomas from B6C3F1 Mice
Benzene and ethylene oxide are multisite carcinogens in rodents and classified as human carcinogens by the National Toxicology Program. In 2-year mouse studies, both chemicals induced mammaryExpand
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Chemicals associated with site-specific neoplasia in 1394 long-term carcinogenesis experiments in laboratory rodents.
The carcinogenicity data base used for this paper originated in the late 1960s by the National Cancer Institute and since 1978 has been continued and made more comprehensive by the NationalExpand
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