J. Hueso-Rodríguez

Publications19
h-index12
Citations329
Highly Influential Citations8
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Identification of a Series of Tricyclic Natural Products as Potent Broad-Spectrum Inhibitors of Metallo-β-Lactamases
ABSTRACT This work describes the discovery and characterization of a novel series of tricyclic natural product-derived metallo-β-lactamase inhibitors. Natural product screening of the Bacillus cereus… Expand
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Compound library management.
TLDR
The increasing size of the collections used for drug-discovery purposes has demanded both hardware and software automation of compound management in order to cope with the increasing demands of HTS. Expand
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A New Chaetoglobosin Isolated from A Fungus of the Genus Discosia
Abstract A new chaetoglobosin, named chaetoglobosin P (1) has been isolated from a fungus of the genus Discosia and its structure elucidated by spectroscopic analysis in comparison with published… Expand
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New cytochalasins from the fungus Xylaria hypoxylon
Abstract Six new cytochalasins together with the known compounds cytochalasins Q, 19,20-epoxy Q and R have been isolated from the fermentation broth of the fungus Xylaria hypoxylon. The structures of… Expand
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Structures of polysporins A-D, four new peptaibols isolated from Trichoderma polysporum☆
Abstract The structures of four new peptides isolated from the fungus Trichoderma polysporum have been ascertained by LC/MS and NMR experiments. All of them are composed of 20 residues with a high… Expand
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A New Destruxin as Inhibitor of Vacuolar‐Type H+‐ATPase of Saccharomyces cerevisiae
In the course of our screening efforts to discover small molecules as selective inhibitors of vacuolar‐type H+‐ATPase of Saccharomyces cerevisiae, we have identified eight active destruxins, 1–8,… Expand
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Novel sesquiterpenoids as tyrosine kinase inhibitors produced by Stachybotrys chortarum
Abstract In the course of screening for small-molecule inhibitors to Tyrosine kinase receptor seven novel K-76 derivatives ( 1–7 ) have been isolated from the fungal culture of Stachybotrys… Expand
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Ent-2α-hydroxy-13-epi-manoyl oxide from Sideritis perfoliata
Abstract A new ent -13-epi-manoyl oxide derivative was isolated from the aerial part of Sideritis perfoliata . Its structure, ent -2α-hydroxy-8,13β-epoxy-labd-14-ene, was established by chemical and… Expand
  • 16
A novel ergot alkaloid as a 5-HT(1A) inhibitor produced by Dicyma sp.
In the course of a search for small-molecule inhibitors of 5-hydroxytryptamine receptors we have identified a novel ergoline derivative (1) from the fungal culture of Dicyma sp. This compound has a… Expand
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Synthesis and absolute configuration of drim-9(11)-en-8-ols from Aspergillus oryzae
Abstract An enantiomeric synthesis of the drimane sesquiterpenes 1 and 2 has been achieved starting from the diterpene (+)-royleanone ( 3 ) via its derivative 5 . This result establishes that the… Expand
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